Study Of Mechanism On Treating Vascular Dementia With XingNaoQiZhi Capsule

Objective: Vascular Dementia (VD hereinafter) subordinates to the disease scope of dementia of old age in the light of TCM (tradditional Chinese medincine). In the recent years,with the aging of population the prevalence of vascular dementia is on the rise and affects seriously the people's working ability as well as living quality. Therefore,it's of great significance to make deeper research on it's pathological mechanism and develop the effective medicine with the integration of Chinese and western medical theories. Based on the conventional knowledge and the modern research achievements of TCM on VD, we developed XingNaoQiZhi capsule with the function of benefitting liver and kidney, promoting blood circulation and resolving phlegm.In order to make probe into its treatment action mechanism, we adopted VD model of kunming mice with the operation of cerebral ischemic reperfusion , observed its effect on praxiology, neurotransmitter, pathomorphology, cell proliferation and Apoptosis of hippocampus, the expression of NGBmRNA, etc.Methods:Part One The effect of XingNaoQiZhi capsule on praxiology and cerebral pathomorphology of VD miceWe duplicated the model of VD mice with the cerebral ischemic-reperfusion operation with the ligation both side carotid artery. 360 Kunming mice were divided into six groups at random , which were sham-operation group,model group, high dose of XingNaoQiZhi capsule group(which were abbreviated to"High-dose group"in the following), low dose of XingNaoQiZhi capsule group(which were abbreviated to"low-dose group"in the following), extract of Ginkgobiloba control group(which were abbreviated to"Ginkgobiloba group")and Nimodipine control group(which...