Study On Correlation Between Osteopontin And Pituitary Adenomas Invasiveness

Backgroud Pituitary adenomas is a common tumor in clinical works, and is about 10% of intracranial tumors. Histopathology proved pituitary adenomas is a benign tumor. But some of the tumor appearing aggressive biological behavior, is so called invasive pituitary adenomas. Invasive pituitary adenomas tend to break through the capsule and invase into the neighbour structure such as dura, nerve, bone, cavernous sinus and even internal carotid. The invasiveness of pituitary adenomas lead to high recurrency and residucy. Now the invasiveness is the hot topic and nodus on pituitary adenomas. Osteopontin ( OPN ) is a secreted phosphate-protein. Its' receptor including integrin and CD44 . Study shows that OPN is related to many tumors on invasion, metastasis, and even the tumor volume. We find no report and study about OPN on the invasiveness of pituitary adenomas. In this study we have investigated the expression of OPN mRNA and OPN protein in pituitary adenomas, the relationship...