Application Of Detection Adhesion Molecules In Diagnosis And Treatment For Cerebral Infarction

Objective To evaluate the value of detection adhesion molecules for the diagnosis and treatment of cerebral infarction. Methods By flow cytometry and enzyme-lined immunosorbent assay,the expression of adhesion molecule on leukocyte﹑platelets,platelet-leukocyte aggregates and the concentrations of soluble adhesion molecule from peripheral blood were measured in patients with carotid atherosclerosis(CAS)and cerebral infarction. The expression of adhesion molecule on endothelial cell were detected by immunohistochemistry and in situ hybridization in rat cerebral ischemia/reperfusion models. Results The expression of platelet membrance glycoprotein was increased in patients with CAS and it was an independent risk factor in CAS.The expression of adhesion mocules on leukocyte﹑platelets,platelet-leukocyte aggregates and the concentrations of soluble forms were elevated in CAS with infarction patients compared to without infarction.Adhesion molecule was an independent risk factor in CAS occurring cerebral infarction.Soluble intercellular adhesion molecule-1(sICAM-1) was a independent risk factors in nonembolic ischemic stroke recurrent.The treatment of bartroxobin and Tong Xin Luo involved in adhesion molecules.Conclusions Adhesion molecules may as a index of predict and treatment monitoring for cerebral infarction.