The Woman Of Child-bearing Age Special Time Commonly Used Chinese Traditional Medicine Heredity Security Research System Constructs And Practices

Objective After observing After observing MNPEC,TA reverse mututation,CHL chromosomal aberration for Yang Jing Zhong Yu Tang, It is able to open out its genetic toxicities. After observing MNPEC,TA reverse mututation,CHL chromosomal aberration for Shou Tan Wan, It is able to open out its their genetic toxicities. After observing MNPEC,TA reverse mututation,CHL chromosomal aberration, It is able to open out its genetic toxicities.. These will provide experiment gist to apply drugs for women.Methods The study adopts filling stomach to KM mouse with 100g/kg,and sets up differ time points with 24h,48h. We adopt differ dosages with 25g/kg,50g/kg,100g/kg,and take timbers after 24h,on MNPEC of the mouse marrows for three compounds.To observe genetic toxicity on Shoutai wan,Yang Jing Zhong Yu Tang and Tong Ru Dan,The study adopts mixing into utensil technique,and sets up differ dosages with 0.8,3.1,12.5,50.0 and 200.0mg/utensil,the experiment effects indicate that it is't affected to TA97,TA98,TA100 and TA102 Shoutai pills,Yang Jing Zhong Yu Tang,under existed S9 or on-existed S9, and we observe TA bacterial reverse mutation.The study adopts cell training means to observe CHL chromosomal aberration for Yang Jing Zhong Yu Tang,Shoutai pills. Tong Ru Dan with 5000,2500,1250μg/ml, and take timbers after 24h and 48h, under existed S9 or on-existed S9, we observe TA bacterial reverse mutation.Results According to the specialty of Traditional Chinese Medicine, The study adopts reformative technique and means of inherit toxicity, we educe experiment results.: The study adopts filling stomach to KM mouse with 100g/kg, and sets up differ time points with 24h,48h, the experiment effects indicate that it is't affected to MNPEC of the mice marrows with differ time points (P>0.05)。but it is distinct difference on MNPEC of the mice marrows for the masculine control groups and the negative control groups, it indicates that it is a credibility system。We adopt differ dosages with 25g/kg,50g/kg,100g/kg, and take timbers after 24h, it is't distinct difference in differ groups on MNPEC of the mouse marrows for three compounds.To observe genetic toxicity on Shoutai pills,Yang Jing Zhong Yu Tang and Tong Ru Dan, The study adopts mixing into utensil technique, and sets up differ dosages with 0.8,3.1,12.5,50.0 and 200.0mg/utensil, the experiment effects indicate that it is't affected to TA97,TA98,TA100 and TA102 Shoutai pills,Yang Jing Zhong Yu Tang, under existed S9 or non-existed S9, and we observe TA bacterial reverse mutation, it is't affected in differ groups。But in range of 150.0 -400.0mg/utensil, the experiment effects indicate that it is affected to TA97,TA98,TA100 for Tong Ru Dan, under non-existed S9, and we observe TA bacterial reverse mutation, it is distinct difference in differ groups。The study adopts cell training means to observe CHL chromosomal aberration for Yang Jing Zhong Yu Tang,Shoutai pills,Tong Ru Dan with 5000,2500,1250μg/ml, and take timbers after 24h and 48h, it is't distinct difference in differ groups on CHL chromosomal aberration for Yang Jing Zhong Yu Tang,Shoutai pills,Tong Ru Dan in differ dosages, it is distinct difference on CHL chromosomal aberration for the masculine control groups and the negative control groups, it indicates that it heve not genetic toxicity on Yang Jing Zhong Yu Tang,Shoutai pills,Tong Ru Dan.Conclusions After observing genetic toxicity on Yang Jing Zhong Yu Tang,Shoutai pills.under existed S9 or non-existed S9, the experiment effects indicate that it is't affected to TA bacterial reverse mutation in 200.Omg/utensil, but under non-existed S9, the experiment effects indicate that it is affected to TA 97,TA 98,TA 100 bacterial reverse mutation in range of 150-400.Omg/utensil. The study adopts filling stomach to KM mice, and adopts differ dosages with 25g/kg,50g/kg,100g/kg, we take timbers after 24h, it is't affected in differ groups on MNPEC of the mouse marrows.under existed S9 or non-existed S9, the experiment effects indicate that it is't affected to CHL chromosomal aberration in the differ dosages.