Anti-inflammatory Mechanism Of Ulcerative Colitis. Jiechangkang Research And Clinical Observation

Objective: Chronic nonspecific ulcerative colitis (CNUC)is called ulcerative colitis(UC)in short.It is a kind of Chronic inflammatory diseaes .The cause of it doesn't definite .The main presentation of it are as follows intermittent diarrhoea with mucus and blood at stool,epigastric pain,tenesmus and constipation of few patients. Some companied with joint Skin eye , mouth , liver and gall disease and so on. It is always lingering ,refractory and easy to relape. In recent years,the research about its etiopathogenesis has made great progress , especially on the mechanism of molecular immunology .So far, we have been lacking of effective remedies for curing it.In order to find an effective ways to cure it, during the past years, the scholars of home and abroad have been intent on the study of Tradition of Chinese Medicine (TCM), ,Which had so curative effect on UC ,But they hadn't been compared in themselves and made conclusive evidence . JieChangkang-1, Which has experience of notability digestion -department of internal medcine specialist with the integration of TCM-WM, which name is Chen Ru-shan, he has make a progress for treatment UC with TCM . This subject is about immunoregulatory and treatment effect of JieChangkang-1, on molecular level by making rat model of UC especially they were observed the action of UC on T-lymph cellCD4/CD8,CD54, the IL -6 of the sernm with rat model of UC ,the nucleus -factor of rectum tissue et al, and make a progress for treatment UC with TCM.Through the clinic treatment of 100 patients ,include 50 JieChangkang-1 group and 50 BuPiYiChangWan group,the effect is 96%,mines treatment effect of JieChangkang-1 had so curative effect on UC.Methods: In the experiment 60 SD rate were randomly divided into 4 groups ,Three of groups had 15 rats,the other s had 10 rats(male or female is averagely),namely the normal control group ,the pathologic control group the Big group or little group, and experiment group. Except the normal control group, the other three animal model groups of UC were made through the integration of general immunity and local stimulation (2,4,6-Trinitrobenzoic acid and 50% alcohol).the six animal...