| In this article, two parts are included. One is the literature review,and the other is study report.The author reviewed literature on photosensitivity research in traditional Chinese medicine in aspects of internal and topical treatment, laboratory research progress was also mentioned.Objective: 1. The aim of clinical research was to observe the effect of anti-photosensitivity mixture in treating polymorphous light eruption(PLE) and photoallergic contact (PACD).2. The aim of experimental research was to investigate the influence of anti-photosensitivity mixture to the apoptosis of epidermal cells of BALB/c mice irradiated by UVB.Methods:1.67 patients were divided into treatment group and positive control group. Pruritus, erythema, papule, blister, erosion, exudation, crust, accompany symptom, safty were measured after using the medcinces and the differences of improvement of symptoms and antipruritus were evaluated.2. BLAB/c mice were divided into treatment group, negative and positive control groups, and then irradiated with UVB in dosages of 300 mJ/cm2 for once. The apoptotic cells, immunohistochemistry of Fas and Caspase-3, immunofluorescence staining of TNF-αwere detected.Results:1.The total curative and effective rate of anti-photosensitivity mixture is 71.1%; the total curative and effective rate of control group is 45.47%, anti-photosensitivity mixture showed better effect with control group.2. At experimental research, anti-photosensitivity mixture showed simlar effects with positive control group.Conclusions:According to the result, anti-photosensitivity mixture showed that it could treat the photosensitivity effectively, with the mechanism of modulate keratinocyte apoptosis.
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