The Research Of The Treatment For Benign Prostatic Hyperplasia Disease Rat Model Hormone Levels And The Influence Of Ki-67, VEGF Expression With San Chong

Objective:According to the pathogenesis of benign prostatic hyperplasia (BPH), we created a BPH decoction made by some traditional Chinese medicine with pertinence. We want to improve the validity of BPH decoction by experimental research, preparing for the new medicine to treat BPH in clinic.Methods:We divided 60 SD male rats randomly into 4 groups: normal group, model group, Longbitong group.and BPH decoction group. We made model of BPH by injet testosterone propionate every day. Then give the normal group and model group oral administration of 0.9% NS, give the Longbitong group oral administration of Longbitong solution, give the BPH decoction group oral administration of BPH decoction. After 30 days of treatment, we kill the rats and observed the weight and cubage of the prostate, the ratio of dry and wet weight of the prostate, the content of testosterone(T) and estradiol(E2) in the rat’s blood. And observe the microcosmic change of the rat’s prostate by microscope.Result:Compared with the model group, BPH decoction can obviously restrain the hyperplasia of prostate(P<0.01). And it is also bettet then the Longbitong group.Conclusion:According to the pathogenesis of benignprostatic hyperplasia (BPH), we created a BPH decoction made by some traditional Chinese medicine with pertinence. It can obviously restrain the progress of BPH. And it is better than the patent medicine of Longbitong.