Study The Puhui San Jia Wei In The Patients With Hyperuricemia And Mechanism Research In Animal

PuHui San, recorded in traditional Chinese medical literature of Jin Gui Yao Lue,composed of Pollen Typhae (PT) and Talcum (Ta), has long been used in traditionalChinese medicine for eliminating heat, excreting dampness, anti-edema, and diureticprescription. The eliminating heat and excreting dampness were used to assess theeffect and mechanism in those who were hyperuricemia.In clinical trial, after administration of PuHui San Jia Wei for 3 and 6 months,the serum uric acid concentration was decreased, but serum cholesterol, triglyceride,creatinine and glucose AC as compared wth control were not signifnicant.In animal trial, administration of aqueous extracts of PuHui San for 6 daysattenuated serum uric acid levels and significantly augmented urinary uric acid levels.were in a dose-dependent manner in normal and hyperuricemia rats. Otherwise, PuHuiSan was not able to produce decrease in both xanthine dehydrogenase (XDH) andxanthine oxidase (XO) activities in hyperuricemic rats liver.There are no significant difference on urinary creatinine, serum potassium andsodium levels and the urine to water intake ratio in normal rats and hyperuricemic rats,as compared with control groups.The research showed that the mechanism of antihyperuricemia of the PuHui Sanwas decreased serum uric acid and increased the amount of urinary uric acidelimination, sut was not able to produce decreasedin both XDH and XO activities in liver and without obvious diuretic effect.It is therefore suggested that PuHui San represents a new type of hypouricemicagent and it may be a potential agent for the treatment of hyperuricemia and gout inclinical use.