Study On The Correlation Between TNF - α And IL - 6 In Patients With Dyslipidemia And TCM Syndromes

Dyslipidemia is due to the body resulting in lipid metabolism of cholesterol (TC) elevated triglyceride (TG) increased high-density lipoprotein (HDL) appears to reduce a disease which one or more indicators. Dyslipidemia refers to abnormal plasma lipid quantity and quality, according to the clinical classification include hypercholesterolemia, hypertriglyceridemia, mixed hyperlipidemia and low high-density lipoprotein hyperlipidemia. AS dyslipidemia closely with its TC, LDL-C level is an independent risk factor for AS, while dyslipidemia or coronary heart disease, a prelude to the stroke, peripheral arterial occlusive disease, pancreatitis and other diseases. With the rapidly increasing economic development and job pressures, more and more people in the long-term excessive intake of high-fat diet, lack of exercise, but the long-term sick lifestyle, which makes dyslipidemia incidence increased year by year, which triggered AS, coronary heart disease, stroke high mortality, morbidity disease is causing huge social human, financial losses." Nutrition and health status of Chinese residents (2004)," reported:My adult prevalence rate of18.6%dyslipidemia, the number of patients is about1.6billion. It is predicted that by2020the global cardiovascular deaths may total number of cases of death by36%, ranking first in the etiology of a variety of human mortality [1]. Looking for effective drug prevention and treatment of dyslipidemia, to protect human health and improve quality of life and reduce health costs of social significance.Objective:Because medicine is no discussion about dyslipidemia, and its often without much obvious symptoms until the disease caused, if starting from a symptom -based diagnosis and treatment ideas, it is difficult for effective early treatment of dyslipidemia. Therefore, in this clinical observation, we dyslipidemia correlation detection indicators from start to combine it with medicine dialectical theory, looking for new ideas from objective indicators of diagnosis and treatment.In the present study, we collected after diagnosis of lipid testing data related syndromes in patients with dyslipidemia, and through its serum inflammatory factors IL-6, TNF-α to detect, analyze and inflammatory factors syndromes relationship explore the possibility of dyslipidemia syndrome type of conduct from the micro indicators.Methods:Research methods prospective, randomized, controlled. In patients with hyperlipidemia as the research object, by collecting serum samples analyzed by centrifugation cases, collection and collation of data and clinical symptoms, syndromes determination performed, all data through SPSS19.0statistical software for statistical analysis, determination of inflammatory factors and syndromes relations, so as to be dyslipidemia TCM syndrome type provide the basis for the micro indicators.Research:Screening patients with dyslipidemia in patients Fangshan District, Da Shan Community Health Center clinic, according to the corresponding inclusion and exclusion criteria for case collection, informed consent, patients generally collect information and related history of the disease, the clinical fill study table, refer to the "Chinese medicine clinical research guidelines" division patient syndromes. Morning fasting blood samples were collected, serum lipids by the Fangshan Da Shan community health service centers outpatient laboratory testing. Blood specimens measuring IL-6and TNF-α after testing. Analyze the relationship between lipids and inflammatory factors and various syndromes between the normal group.Results:This study collected a total of140cases, including20cases of normal control group, and the other120cases of hyperlipidemia. Liver and kidney group (40.83%)> hyperactivity group (25.83%)> phlegm repressor group (20.83%)> spleen deficiency group (8.33%)> stasis group (4.17%).①dyslipidemia patients generally tall men than women, while age and body mass index (BMI) did not differ significantly.②according to the number of patients and the frequency distribution of syndromes, the highest prevalence of liver-kidney, followed by descending order of hyperactivity>phlegm repressor type>spleen deficiency type> stagnation type.③serum TC levels:comparison of the normal control group, in addition to spleen deficiency group, TC content of each of the other groups significantly increased, there was a significant statistical difference (P <0.05); blood stasis group was significantly higher than TC liver and kidney yin group and the group, the difference was significant (P<0.05), the rest of the packet syndromes no significant difference between the TC level.④serum TG levels:phlegm repressor group, hyperactivity group than in the control group TG levels were significantly increased, the difference was significant (P<0.05), no significant difference compared with other syndromes grouped normal TG levels; phlegm repressor group TG levels were significantly higher hyperactivity group, the difference was significant (P<0.05), other syndromes group no significant difference between TG levels.⑤serum HDL levels:no significant difference between the groups.⑥hyperlipidemic serum IL-6levels were significantly increased compared with normal control group, the difference was significant (P <0.05).⑦There are various comparison between TCM syndrome in each group and the normal control group, IL-6significantly different (P<0.05), serum IL-6levels within each group in the order of:spleen deficiency syndrome> Yin Yang Kang syndrome group> stasis syndrome group> phlegm syndrome group repressor> liver and kidney syndrome group> control group.⑧hyperlipidemic serum TNF-a levels of viremia group was significantly higher than the normal control group, the difference was significant (P<0.05).⑨have various syndromes and normal control group comparison among groups significant differences (P<0.05), serum TNF-α levels within each group in the order of:liver and kidney syndrome group> Yinxuyangkang syndrome group> phlegm syndrome group repressor> stasis syndrome group>spleen deficiency syndrome group>control group.The main conclusions:Preliminary clinical indicators from observational studies of view:①The case suggests the presence of men gather prevalence in women may be in the area;②hyperlipidemia onset of liver-kidney prevalent in the region, and for the yin yang Kang type, phlegm repressor type, spleen and kidney yang and qi stagnation type in the incidence of low frequency in the region; serum TC③hyperlipidemia in patients with various syndromes, TG levels are different than the normal control group, while no significant difference in HDL, blood stasis group of patients mainly for elevated levels of TC, phlegm deter patients mainly elevated TG levels;②normal and hyperlipidemic serum levels of inflammatory cytokines IL-6There are different and TNF-α, and serum levels of inflammatory cytokines hyperlipidemia index higher than the normal group, IL-6levels in the order of: spleen deficiency group> Yinxuyangkang>stasis>phlegm deter>liver and kidney>normal group, TNF-α levels in the order of:liver and kidney group> Yinxuyangkang group>phlegm repressor group>stasis group>spleen deficiency group>control group...