Protective Effect Of Baogan Granule On Alcoholic Liver Injury

Purpose:Comprehensive survey of ancient and modern documents,realve the discipline of alcoholic liver injury syndrome differentiation and medicine usage.Screening out the small TCM prescription-baogan granules that has reason,theorem,modus,chinese medicine,to proved protective effect of Baogan granules on alcoholic liver injury by experimental verification.Lay the foundation for the subsequent development of varieties of TCM.Material and method: 1.Theoretical Study Inductive statistics the syndrome differentiation and medicine usage for alcoholic liver injury through searching the ancient and modern TCM documents on Puji Fang data base management system and document retrieval system of ZYEB,CNKI,CQWP.In order to create small prescription-Baogan granules to effective alcoholic liver injury. 2.Experimental Study Grouping and given medicines to mice.After manufacture of alcoholic liver injury model to mice, get the blood and liver of mice. 1.Research Baogan granules effect liver function in mice that have alcoholic liver injury:test content of ALT,AST,TBIL in mice serum. 2.Research Baogan granules effect lipid metabolism in mice that have alcoholic liver injury:test content of TG,HDL,LDL in mice serum 3.Research Baogan granules effect lipid peroxidation in mice that have alcoholic liver injury:use colorimetric analysis tested content of GSH,MDA,SOD in mice Liver tissue. 4.Research Baogan granules effect Inflammatory cytokines in mice that have alcoholic liver injury:use ELISA tested content of TNF-α,IL-1 in mice liver tissue. 5.Research Baogan granules effect Liver tissue morphology in mice that have alcoholic liver injury:with HE staining to observed Histopathological changes.Result: 1.Ancient and modern physicians believe is SHIRE for alcoholic liver injury. Ancient mostly used medicine that LIQI,SHENSHI,HUASHI,BUYI.Morden mostly used medicine that HUOXUE,SHENSHI,HUASHI,BUYI. 2.Baogan granules could reduce contents of AST, ALT in mice serum.But is not clear to inhibit contents of TBIL. 3.Baogan granules could reduce contents of TG,LDL in mice serum,and could promote contents of HDL. 4.Baogan granules could reduce contents of MDA in mice serum, and could promote contents of GSH,SOD. 5.Baogan granules could reduce contents of TNF-α and IL-1 in mice serum.Conclusion: 1.The most basic and common pathogenesis is SHIRE for alcoholic liver injury. 2.Baogan granules has protection on alcoholic liver injury in mice 3.Baogan granules have functions that reduce transaminase,promote metabolism of liver for lipids,resist lipid peroxidation of live and resisit inflammatory changes of liver.