Studies On Pharmacokinetics Of "Fuzhengjiedusan" And Its Super-powder In Chickens Artificially Infected With Infectious Bursal Disease(IBD)

"Fuzhengjiedusan"is Chinese traditional medicine in Chinese Veterinary Pharmacopoeia (2000 version) which is mainly composed of radix isatidis, astragal, and aceranthus sagittatus. The"Fuzhengjiedusan"which could be shattered into below 10μm by the jet mill and by this way the intercellular wound be destroyed and could be absorbed easily by the chickens to produce good antivirus actions and therapeutic role on diseases. So Chinese traditional medicine specialists pay more and more attention on it because of its safety, lower price and preventing drug tolerance in some degree. Through prophase clinical certification of pharmacodynamics that the traditional Chinese medicines and their super-Chinese crude drugs have effective antivirus actions and therapeutic roles on IBD. While the studies on pharmacokinetics of the traditional Chinese medicines is few in our domestic. In this paper the pharmacokinetics and their relative bioavailability of the two preparations of Chinese traditional medicines in the chickens infected with IBD were studied, and the results can provide reasonable fundamentals for establishing administration dosage and developing new dosage forms.In this paper, the pharmacokinetics and their relative bioavailability of indirubin and polycose were studied by the method of HPLC and Anthrone- vitriolic acid chromatometry respectively. The concentration-time data were analyzed with the pharmacokinetic computer program MCPKP. The results showed that the concentration–time course of polycose in plasma can be described by a two-compartment open model with first order absorption after the experimental chickens were oral taken with the"Fuzhengjiedusan"(5g·Kg^-1), its theoretical equation was: C₁=31.7514e^-0.0098t+4.6994e^-0.0019t-36.4508e^-0.0271t, and the main pharmacokinetic parameters were as following; C_max=8.5690μg·mL^-1, AUC=2864.4mg·Kg^-1·min^-1,Tp=66.8297min,Tcp=1031.8min. The concentration-time course of indirubin in plasma can be described by a one-compartment open model with first order absorption , its theoretical equation was: C₂=1.2107(e^-0.0043t-e^-0.0231t), the main pharmacokinetic parameters were as following: AUC=61.803mg·Kg^-1·min^-1,Tp =94.9151min,Tcp=774.46min.After oral administration of the super Chinese crude drug(5g·Kg^-1), the plasma concentration-time data of polycose in chickens was fitted to a first-compartment open model with...