Study On Innocuity And Piglets' Immune Performance Of Compound Astragalus Polysaccharides Injection

In order to study the innocuity tests of compound astragalus polysaccharide injection, 50 Mus musmus-culus were randomly divided into 5 groups. Selected two rabbits into two groups for local irritant test, 90 weaned pigs at 42 days randomly divided into three groups, were injected different dose compound astragalus polysaccharide injection, and were observed blood index of the injection. 6 rabbits were randomized into three groups to study temperature test and hemolytic test, Selected 20 piglets at 21 days, randomly divided into four groups for swine pest blocking test, 150 suckled pigs at 1 day for 15 nests were randomly divided into 3 groups for new three needles care, and to be observed its health effects of pigs' growth performance. The results showed that: the LD50 of the compound astragalus polysaccharide injection for musmus-culus was 0.95mL. After the local injections in rabbits, the stimulating was in a low, was absorbed well. After intramuscular injection at neck for 3mL, 6mL per pig, RBC and PLT in blood were improved in a certain extent, the difference was obvious (P<0.05), and HCT also had increased in certain degree, but there was no significant difference (P>0.05), and the WBC and HGB had been lower in certain degree, but no significant difference (P>0.05), the WBC was higher relatively, it's possible which had some inflammation, the total protein and albumin in blood increased appropriately, the proportionality of albumin and globulin (A/G) were in the normal range, and there was no significant difference before no giving medicine (P>0.05), compared with the control group, all kinds of indexes in blood had no significant difference (P> 0.05). Compound astragalus polysaccharide injection was almost a non-toxic, nonirritant injection; the dose of 3-6mL per pig had no obvious effects on blood biochemical indicators, and a clear improvement on blood physiological indexes. The rabbits body temperature tests showed that, the control group with positive enrichment temperature changes were greater than 1.5 degrees, there is no significant difference (P>0:05), and has high heat; Its hemolytic test showed that the hemolytic rates were lower than 0.5%, rabbit RBC's microexamination was observed had no hemolysis. Showed that it could not kill directly vaccine virus, and it didn't cause hemolysis. The immunopotentiation experimental results showed that, three experimental groups had an antibody levels greatly improved, and it were 100%, and the control group was compared with relatively low level of antibodies. The new three needles health care groups were better than traditional three needles care group, the incidence rate of diarrhea was lower 16%, other illnesses were lower 20%, there were more than 12.6% weight gain, but no significant differences (P> 0.05), and it's difference significant compared with the control group (P<0.05), it could obviously increase the pigs serum levels of immunoglobulin IgG and IgA, and difference significant (P<0.05).