Study On Effect Of Dissipate Excessive Stagnation Of Fire Principle In The Adjustion Of Aggressive Factors And Protective Factors In Experiment Rat's Of Gastric Mucosal Damage Caused By Mezolin

As a kind of highly easy recurrent diseases of multiple causes, the main disease mechanism of gastric mucosal damage chiefly lies in the mutual disorder of aggressive factor and protective factor caused by the regulation abnormality of neurohumor. The frequent recurrence of the disease can greatly affect the patients' living quality and 1ife security. Medicines with the function of reduceing gastric acid, rooting out the HP infection and strengthening the gastric mucosa protection are always abopted by modern medicine, which proved unsatisfactory result and no superiority in anti-recurrence. As the creation of prof. Tian Shuxiao through more than thirty years of clinical experience, Weikang capsule is a compound Chinese herbal product with safe efiect and lower recurrence rate in treating gastric mucosal damage diseases in clinic. This paper made a reserch on the effect of relevant cytokine involved the onset; development and healing of gastric mucosal damage diseases.We made the acute gastric mucosal damage with 40 Wistar rats and made them take Weikang capsule. And compared with the vacancy group the results suggested that the capsule could reduce the PAF and TNF-α content in blood plasma cytokine of experimental gastric mucosal damage rats and increase content of EGF and PGI2, inhibit the increase of gastric acid secretion, decrease the recurrence rate of gastric mucosal damage. The capsule also can alleviate uleury degree of gastric mucosa and prevent the formation of gastric mucosal damage. Pathological picture analysis showed that the capsule could treat gastric mucosal damage effectively and hasten the healing of the damaged gastric mucosal.We a1so made another experiment of the acute model with 40 wistar rats to observe the effect of Wiekang capsule in adjusting content of MDA and SOD in gastric mucosal. The result showed the capsule could depress the damage of LPO to prevent the onset of gastric mucosal damage effectively.In short,Weikang capsule could prevent the onset of gastric mucosal damage by weakening aggressive factors and strengthening protective factors．...