Expression And Correlationship Of P-gp,p21～(ras) And CD44v6 In Primary Lung Carcinoma

ObjectiveiTo investigate the relationship of the expression of P-gp, p21ras and CD44v6 in primary lung carcinoma and their clinicopathological significance. In order to offer a new idea to diagnosis, prevent and treat primary lung carcinoma.Methods: The expression of P-gp, p21ras and CD44v6 were investigated by immunohistochemical SP method in 79 cases of primary lung carcinoma. The relationships were also analysed between the results and clinicopathological features. 55 cases with following-up data were studied by Kaplan-Meier survival Curve and the Cox regression analysis. 11 cases of adjacent tissues acted as control group.Results:1. Of the 79 cases primary lung carcinoma, the rates of expression of P-gp, p21ras and CD44v6 was 74.69% (59/79) , 84.81% (67/79) and 51.09% (41/79) respectively.2. The expression of P-gp, p21ras and CD44v6 were related to the different sorts of primary lung carcinoma (P < 0.05) . There was no marked significance relation to age, sex, smoke, metastasis of lymph nodes, as well as prognosis.3. The co-positive-expression rates of P-gp and p21ras ,P -gp and p21ras and, p21ras and CD44v6 was 67.09%(53/79), 43.04% (34/79) , 45.57%(36/79) respectively , a significant correlation was observed between P-gp and p21ras.4. All of 21 cases which sizes were not more than 3cm (Diameter ^3 cm) expressed p21ras, but the expressive rates of those which sizes were more than 3cm (Diameter>3cm) only 79.31 %(48/56) (P < 0.05) .5. The results of multivariate analysis by the Cox proportional hazards model showed that TNM stage was an independent prognostic indicator.Conclusions:1. There is a significant relationship between the expression of P-gp, p21ras and CD44v6 and the different sorts of primary lung carcinoma (P<0.05) .2. There is a cooperative action between the expressions of P-gp and the expressions of p21ras.3. The significance and its mechanism of the expression of CD44v6 in primary lung carcinoma should be further studied.4. TNM stage is an independent prognostic indicator for primary lung cancer.5. The expressions of P-gp. p21ras and CD44v6 are not an independent prognostic factor of primary lung carcinoma.