Investigating The Inflammatory Pathogenesis Of Treating Asthmatic Guinea-pigs By Acupoint Application

BACKGROUND: Bronchial asthma exceeding 10% prevalence rate in world is a common and frequent disease of airway reactive chronic inflammation which may lead to increase airway reactivity and cause the different, extensive and reversible obstructing airway ventilation clinical symptoms that are gasping dyspnea suddenly and repeatedly, suffocating feeling and cough with or without foamed sputum; and physical signs are widespread wheeze heard in lung and bronchus, increased respiratory rate, elongated expiration phase, as severity so that accessory respiratory muscle exertion (three depressions sign), inequality in pulse strength (paradoxical pulse) and dripping wet much in sweat, et al; Not only these symptoms and physical signs can be remission by oneself or through therapy rapidly, but also attack to last or repeatedly. The genius morbi of Bronchial asthma have been considered of that extensively allergic airway obstruction could be restoration oneself or after therapy as a result of short-term bronchial hyperresponsiveness (BHR) during mostly days of last century (20th century). This operable definition conduced to distinguishing others chronic obstructive pulmonary disease (COPD), then the focal point of studies about pathogenesis of asthma has been displaced insisting airway inflammation recently 10 years since the end of 20th century. Summarizing literatures concerned with pathogenesis of Asthma recently, it may be induced as follows: (A) Theory of airway inflammation, (B) Theory of disequilibrium in neural receptors, (C) Theory of Immunity and allergology, (D) Other theories correlated episode of Asthma. First of all, respiratory passage inflammation researched in this question for study in Asthma has a focal point emphasized that airway inflammatory disease result from partaken and affected each other by many kinds of cells, medium and cytokines, et al. Secondly, Immunity and allergology of Asthma researched, the asthmatic paroxysm is correlated closely to IgEand receptor of IgE produced in Atopic diathesis; another immunoglobulins and their receptors correlated to asthmatic paroxysm researched, that relates to immediate asthmatic response (IAR) and late asthmatic response(LAR). Asthmatic serious symptoms are occurred, physical signs are showed and pathology is changed when IAR happened. LAR happened late for a long time then the bronchial chronic inflammation is developed continually or pathological phenomenon is kept formerly.Bronchial asthma known by traditional Chinese medicine and science of acupuncture and moxibustion are that: There are the sound of sputum, gasp and bronchus wheeze heard in lung during asthmatic paroxysm, but the corporeity is weak in normal time, then episode is evoked by extra-infection repeatedly. Phlegm is main of etiological factor. The basic pathological process is that "Latent Phlegm" triggered by infection, resulting in the abnormal function of ventilatng upward, cleaning downward in lung and onset of illness happened resulting from the stayed and amassed Phlegm. The major causes are concerned with inveterate Phlegm hidden in lung, congenital or acquired function of kidney and also acquired factors of spleen viscera and stomach organ; The remote causes are induced by extra-vicious factors assault, chopped weather, unsuitable diet, bodies weak after illness, overwork and emotional moody disharmony, etal.Making use of the ?? adrenoceptor analeptic ameliorating bronchial spasm and making use of the medicines of theophylline abateing inflammation and conquering gasp were major clinical means treating Asthma in the past, then glucocorticosteroid has been a primary supervisory and controller at present. Of cause, it is more important that precaution is emphasized and contacting allergen is avoided. At the present stage, there are many insufficient problems which include of a series of side effects could be brought by the major therapy of adrenal cortical hormone, and the problems if patients are able to bear long-term medication and supervisory control in asthmatic preve...