| Chronic renal failure (CRF) is th end of continuous kidney damaging which is caused by all kinds of cause of disease.Because of its serious pathologic damaging that is difficult to reversing,CRF always has a progressive exacerbation up to uremia,which must have a subtitution threapy.High morbility,knotty therapy and unfavourable prognosis are the characteristic of CRF.It is the commonly critical disease and one cause of death in internal clinic.Since 1970s ,dialysis threapy and kidney transplantation's wide carrying out bring a leap in CRF threapy history ,extremely improve the CRF patients' surrival quality,extend their survival age limit.But there are some problem that can't solve easily,which limit those popularization in our country.Those are source of the kidney,tissue matching and expensive fee.Under the present economic circumstances,most patients can't accept dialysis of kidney transplantation.The expensive expense has become a social problem.It has confirmed that the important cause which lead to nephron's progressive damaging is immunologic hypofunction,toxin accumulation, hypercoagulability, hyperlipidemia and so on.And glomerulus sclerosis is the pathologic base of renal function's progressive deterioration in kidney diseases.So the key load to preventing and cureing CRF,to delaying kidney fuction progressive deterioration is intentionally cleaning toxin,improving internal environment,hypercoagulability and hyperlipidemia, adjusting immunologic function and depresing glomerulus sclerosis.CRF belongs to 'edema','uroschesis','consumptive disease' and ect. of Chinese Traditional Medicine.lt has numerous and complicated cause .complex pathogenesis.very long process of disease.In its course of evolution,Vital-qi and pathogenic factor influence each other and become each other's cause of disease until vicious circle takes shape.On clinic the common type of symptoms and signs of CRF is insufficiency of both the spleen and the kidney ,damp-evil and blood stasis.The common property of CRF is body resistance weakened while pathogentic factors prevailing and defieciency and excess existing together. Inview of above-mentioned cognition of both the Chinese Traditional Medicine(TCM) and modern medicine's ,most of the scholar think of that the threpy of CRF must not be part threapy that is one prescription,one drug or one load. And previous experience also confirmed that one drug of one load can't bring ideal effect into play.In consideration of that, being based on the TCM's priciple of treatment that is concept of wholism and strengthening the body resistance to eliminate pathogenic factors,consulting the mordern medicine's cognition about pathogeny.pathogenic and physiologic changes of CRF,my director professor Yang nizhi put forward a tactics of treatment which is combinedtreatment .entirety adjustment. The particular threapy is useing the drug in multi-load for example: oral medication,external application and so on for synergistic effet of multilevel and multiangle to adjust whole body and improve effect. According to long-term clinical practice, she chose the comprehensive measures that is made up of dripping complex prescription red sage root injection intravenous, oraling Niaodukang and Tongmai oral liquid and colon dialysate enteroclysis. That treatment can strengthen the spleen and replenish kidney,promote blood circulation to remove obstruction in the channels.Useing the combined treatment of TCM to treat CRF patients and systemly observing 103 case of the patients,we gain satisfied effect.Based on it .for further study of the mechamism of action, we observe the treating effect of combined treatment of TCM on rats' chronic renal failure induced by 5/6 nephrectomy.The methord of making rats' chronic renal failure induced by 5/6 nephrectomy is resecting 2/3 of left kidney and at the same time removing the right kidney. Then randomly divide into model control group,Chunke group. Tongmai group, colon group,combined treatment group and normal control group. After 4 weeks of treatment ,'samp...
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