| Congenitial cleft lip and palate (CLP) is one of the most common birth defects in human beings, which accounts for about sixty-five percent of all the congenital malformations. The incidence in newborns is about l%-2%. CLP has a serious influence on physical and mental health of patients and their lives, brings about heavy burden for the society and families. Although Hie incidence, concrete etiology and prevention are still the hot topics that scholars at home and abroad are interested in, few studies on risk factors of CLP in ethnic minorities have been reported by standard case-control study in our country until now. According to data of birth defects, we investigated nonsyndromic cleft lip with or without cleft palate (NSCL/P) of Uygur newborns from Jan. 1992 to Dec. 2001 in parts of Xinjiang Autonomous Region. Compared with newborns of the Han nationality, the incidence and variation trend of NSCL/P in Uygur babies were analyzed. Furthermore, a case-control study was conducted to investigate the possible risk factors on NSCL/P in Uygur babies, which provided valuable materials for the prevent and control of the deformity.1. The study on incidence and distribution of NSCL/P in Uygur babies in parts of Xinjiang Autonomous RegionObjective: To explore the variation trend in the incidence and distribution of NSCL/P in Uygur babies in parts of Xinjiang Autonomous Region. Methods:According to data of birth defects, a birth investigate was carried out in parts of Xinjiang Autonomous Region from Jan.1992 to Dec. 2001. Cases with NSCLP were collected from 11 hospitals in Uygur and Han newboms. The incidence and distribution of NSCL/P were analyzed Results: It was found that there were 107 babies with NSCL/P among 108427 Uygur newboms fiom Jan. 1992 to Dec. 2001. Annual incidence of NSCL/P varied from 0.92% to 1.04% and the total incidence was 0.99% The total incidence of isolated cleft lip(CL) was 0.36% and that of cleft lip with cleft palate (CL+P ) was 0.63 %; no significant variation was noted in the annual incidence from 1992 to 2001 ( x 2=0.103, P=1.000) . Of all the 107 cases, CL+P accounted for 63.6%, CL 36.4%; left clefts 44.9%, right clefts 29.9%, and bilateral clefts 25.2%. The ratio of urban and rural area was 1:1.3. There was no significant difference between the urban and rural incidence in statistics ( x2=3.369, P=0.066) . Also no significant difference was found in distribution in four regions ( x2 =0.018, P=0.999) .Among the patients, the male-female ratio was 1.5:1, and the incidence in males(1.18%o) was higher than that in females(0.79%) ( x2 =4.124, P=0.042) . In the samel 1 hospitals there were 283 babies with NSCL/P among the 139629 newboms of the Han nationality during the ten years. Annual incidence varied from 1.96% to 2.18% and the total incidence was 2.03%. The total incidence of CL was 0.72% and that of CL+P was 1.30%; no significant variation was noted in the annual incidence as well ( x 2 =0.253, P=1.000) . Of all the 283 cases, CL+P accounted for 64.3%, CL 35.7%; left clefts 46.3%, right clefts 27.9%, and bilateral clefts 25.8%. The ratio of urban and rural area was 1:1.2. There was no significant difference between die urban and rural incidence in statistics ( x2 =3.156, P=0.076) . Also no difference was found in distribution of four regions( x2 =0.050,P=0.997). The male-female ratio was 1.5:1, and the incidence in males(2.39%) was higher than that in females(1.65%) ( x2 =9.485, P=0.002) . Comparing the annual incidence in the same year and the total incidence of NSCL/P in the Uygur nationality with incidence in the Han nationality, there weresignificant differences in stastics, but no difference was found in distribution. Conclusion: It could be concluded that die incidence of NSCL/P in both Uygur and Han showed no variation trend in parts of Xinjiang Autonomous Region from Jan. 1992 to Dec. 2001. The incidence rate of NSCL/P in Uygur was lower than that of Han ( x2 =42.050, P= 0.000), but the distribution were identical. CL+P was more common than CL. There was...
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