A Study Of Myocadial Protection Of Open-Heart Surgery On Beating Heart

ObjectionTo evaluate effect of myocadial protection of open-heart surgery with beating-heart and mild hypothermic cardiopulmonary bypass(CPB). MethodThirty patients with atrial septal defect or ventricular septal defect were randomly divided into two groups .The patients in control group (B group ) were operated under the middle hypothermal extracorporeal circulation and aortic cross-clamping with cardial arrest while in experiment group (A group) were operated with cannulation of superior and inferior venae caval under light hypothermal extracorporeal circulation on beating heart.Blood samples were taken from peripheral venae for assessing the level of troponin I (cTnl), superoxide dismutase (SOD) , creatine kinase -MB (CK-MB),creatine kinase (CK) and malondiaehye (MDA). The myocardial tissues was taken from auricula dextra for assessing ultrastructure changes . ResultsIn control group the level of cTnI, MDA,CK,CK-MB significantly increased and SOD decreased during CPB. After reperfusion cTnI,CK,CK-MB were significantly higher in control group than those in experiment group, The myocardial ultrastructure changes were significant in control group. Pump stopped immediately at the end of operation .Only a few patients needed low dose of dopamine to stippport circulation and no air embolism . ConclusionOpen-heart surgery with beating-heart and mild hypothermic cardiopulmonary bypass(CPB) could prevent myocardial injury in experiment group .