Pathological Analysis Of Portal Hypertension Gastropathy

Objective: To explore the pathological characters of Portal hypertension gastropathy(PHG), and to analysis the affecting factors of PHG. Methods: Gastric mucosal tissues from 85 patients with PHG(PHG group) were observed under light and electron microscopy, and immunohistochemistry and special stain were also performed. In the meantime, all hepatic tissues from this group were performed immunohistochemistry stain. In contrast with PHG group, Gastric mucosal tissues from 40 normal cases(control group) were observed under light and electron microscopy, special stain were also performed. Results: Vascular changes of the gastric mucosa was the basic pathological characters of PHG, and helicobacter pylori(HP) infection rate was 77.8% in PHG group,oxyntic cells were hyperplasia in some cases, immunohistochemistry stain ofHBsAg and HBcAg was negative in the gastric mucosa, the positive rate of HBsAg and HbcAg immunohistochemistry stain in the hepatic tissues was 94% and 98%,respectively. The HP infection rate in control group was 30%, the HP infection rate in PHG group was obviously higher than those in control group. Conclusion: PHG has it's own relative pathological characters, HP infection and high acid state may be two important affecting factors of PHG. But there were no evidences to prove that hepatitis virus B(HBV) had joined in the course of PHG.