Research On Mechanism Of Syndrome Of Accumulation Of Cold Fluid In The Lung In Asthma

Objective: This thesis expounds systematically the theoretic problems about the syndrome of accumulation of cold fluid in the lung in asthma to enrich the theory of the syndrome. Based on the.pathologic rat models with the syndrome of accumulation of cold fluid in the lung in asthma, the thesis discuss deeply the microcosmic mechanism of syndrome of accumulation of cold fluid in the lung in asthma and the target curative location and the functional mechanism of "Yang-Warming and Fluid-Dispersing Formula" to understand further of the theory of the lung's promoting water metabolism. Methods: This research based on the viewpoints of three theories, namely, the combination of exopathogens and inpathogens, coldness of body and drinking cold tends to impair lung, and overstrain leading to consumption of qi, combining with asthmatic nosogenesis of modern medicine. Pathologic rat models with the syndrome of accumulation of cold fluid in the lung in asthma were set up with the methods of feeding with ice water and food with cold property and swimming in the ice water, while ovalbumin was used to induce rat asthma in the cold environment. The models were treated with "Yang-Warming and Fluid-Dispersing Formula" and Salbutamol. Then observe the relevant indexes including body temperature, avoirdupois, the drink capaticy, arterial blood gas, and expression of β -ARmRNA in lung tissues, etc. Results: The results of the experiment showed that the development of pathologic rat models with the syndrome of accumulation of cold fluid in the lung in asthma which proved to be repetitive is comparatively successful and reliable. General syndromes of the rats in the model group were in accordance with clinical symptoms of patients of the syndrome of accumulation of cold fluid in the lung in asthma. The changes of microcosmic indexes coincided with those of asthma related to the syndrome. For example, the expressive indexes of avoirdupois, body temperature, the drink capacity were alleviated, P_aO₂ , S_aO₂ , tO₂ decreased while P_aCO₂ increased in...