The Variation Of High-Sensitivity C-Reactive Protein And Mononuclear Chemoattractant Protein-1 In Acute Coronary Syndrome

Objective: To examine the variation and clinical significance of serum high-sensitivity C-reactive protein (hs-CRP), mononuclear chemoattractant protein-1 (MCP-1) levels in the patients with acute coronary syndrome.Methods: 136 subjects were included in this study, 24 patients with stable angina pectoris (SAP), 28 patients with unstable angina pectoris (UAP), 34 patients with acute myocardial infarction (AMI) and 50 subjects as the control .The serum levels of hs-CRP and MCP-1 were measured by means of immunosorbent enzyme-linked assay (ELISA) and CK, CK-MB was measured by means of Beckman systems in all subjects.Results: The concentration of all enzymes showed no difference between the control and stable angina pectoris group (P>0.05). The serum levels of hs-CRP and MCP-1 increased significantly in the unstable angina pectoris group (P<0.05), but CK and CK-MB did not increased in the unstable angina pectoris group(P>0.05) as compared with the control group and the stable angina pectoris group. The serum levels of hs-CRP, MCP-1 and CK, CK-MB increased significantly in AMI group as compared with the control group(P<0.05) , the stable angina pectoris group(P<0.05) and the unstable angina pectoris group(P<0.05). There was a significantly positive correlation between hs-CRP and MCP-1(r=0.78, P<0.05).Conclusion: The serum levels of hs-CRP and MCP-1 in the patients with acute coronary syndrome are significantly elevated; the serum levels of hs-CRP and MCP-1 are associated with the severity of the disease (myocardial damage),indicating that inflammation plays an important role in the pathogenesis of acutecoronary syndrome. Compared with Ck and CK-MB, The serum levels ofhs-CRP and MCP-1 are important in the clinical diagnosis of acute coronarysyndrome.