| This thesis collected a lot of old and new, domestic and foreign data and information and synthesized various theories. In order to provide the possible theoretical and experimental evidences for effective prescription which is suitable to treat AD in TCM clinical practice, and also discussed the relative researches of treating Alzheimer's Disease (AD) mainly by invigorating spleen from various theoretical and experimental levels.In the theoretical study section, this thesis considered that the asthenia of spleen and stomach dominates pathological dotage, and AD is the appearance of brain aging. Then according to the theory of the relationship between Zang Organ & emotion, beginning with the point of "spleen storing nutritional essence and nutrient QI(the spleen) housing idea", and using the Spleen-stomach Theory of TCM and the relationship between spleen and brain, this paper probed thoroughly into what important effects spleen and stomach have in the mobility process of AD. We established the basic constitution of treatment to AD, which was invigorating the spleen and reinforcing the essence and removing blood stasis to refresh mental activities and developed the QIANGPI BUJING HUAYU YIZHI Capsule (QPC) to treat AD. Basing on the past effective results of clinical and animal studies, we designed the animal experiment to take further step to reveal the possible mechanism how the method of the treatment acted.In the experimental study section, the rats were divided into four groups, including the normal control, the model, the Piracetam (the western medicine), the QPC (the TCM), and copied to AD model. After the treatment, we observed the effects on the AD rats' ability of leaning and memory, detecting the TChE activity and MAO-B activity of the AD rats' brain hippocampus homogenate, and the TChE activity and MAO-B activity, IL-1 β content, IL-6content of AD rats' blood serum, then comparing the QPC with other groups to reveal the mechanism of action of the QPC treating AD to bright. The results showed that, after treatment the group of TCM rats had been obviously improved the ability of learning and memory in space, with marked differences comparing to the model group(P<0.05. P< 0.01); and had been obviously increased TChE activity and lowed MAO-B activity of brain hippocampus homogenate with very marked difference compared to the model group (P< 0.01) ,and having low levels of IL-1 β content and IL-6 content of blood serum with a marked difference from the model group (P<0.05, P<0.01) . It indicated that QPC could improve the learning and memory ability to treat AD probably through better cholinergic nerve center system and monamine nerve center system and protecting hippocampus neuron, restraining the inflammation reactions which may have relations with the formation of senile plague.
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