Experimental Studies On The Pharmacodynamics And Toxic Effects Of Jiangfu Capsule

Purpose: To study the pharmacdynamics in association with the clinical effect of Jiangfu Capsule, as well as safety application. Jiangfu Capsule consists of Powder for Dried Gingers, Nutgrass Cypressgrass and other Chinese herbmedicines. The TCM preparation for treating cholecystitis. This effective medical prescription has obtained satisfactory clinical effect by making of use many years' medical practice. This formula has function of clearing away heat, smoothing bile, activating blood and relieving pain and antipyretic. Through main pharmacodynamics study on Jiangfu Capsule for treating cholecystitis, it shows good results. In a word, this formula has apparent pharmacodynamics action of anti-flaming, relieving pain, activating blood and smoothing bile. For further exploring function mechanism of Jiangfu Capsule and theoretical foundation for clinic applicaton.Method: Study antiinflammation of the traditional Chinese medicine, main studies for Jiangfu Capsule application, as well as safety application. We observed the anti-inflammatory effect was tested in xylene caused mice ear edema model, carrageenan caused rat's feet edema model; its analgesia effect by hot plate and acetic acid in mice, and causing fever in rat's feet by injecting carrageenan. Toxicology experiments include the long term ( observe 90 days ) toxicity experiment. Experimental animals are first class SD rats. Route of medicine is pour the dosages of the Jiangfu Capsule. Raised with high, mid-, and low dose of the drug, then rats were measured weight, blood routine, liver function, organ index and pathology.Results:1. Anti-inflammation experiments: Jiangfu capsule has the inhibitory for inflammation in rat's feet causing by carrageenan and in mice' ears causing by dimethylbenzene.2. Analgesia experiments: Jiangfu capsule has the inhibitory for pain causing by hot plate and acetic acid.3. Antipyretic experiments: Jiangfu capsule has decreased the of body temperature induced with carrageenan in rats.4. Bile secretion experiments: Jiangfu capsule decreased the serum SB levels in the rats treated with APIT, promoted the secretion of bile and increased the concentration of bilirubin in the bile.5. Antispasmodic experiments: Jiangfu capsule inhibits the contraction of gallbladder smooth muscle of Guinea Fig caused by Ach and normal mice.6. Anti-bacteria experiments: Jiangfu capsule preserved those mice from death caused by abdominal injection of bacillus coli and had a effect against staphylococcus aures , bacillus coli, typhoid bacillus, shigella flexneri, and pseudomonas aeruginosa.7. lx)ng term toxicity experiments: Jiangfu capsule has low toxicity, the clinical dose is safe. It was safe for rats to take Jiangfu capsule doses and period of treatment offered by this paper.Conclusion: Jiangfu capsule has remarkable actions of anti-inflammation and analgesia and antipyretic; it increased bile secretion, antispasmodic and anti-bacteria effect. For further exploring function mechanism of Jiangfu Capsule and theoretical foundation for clinic applicaton. Jiangfu capsule has low toxicity, the clinical dose is safe.