Expression Of Nuclear Factor-kappa B In Cervical Cancer And Its Clinical Significance

Objective To investigate the expression of Nuclear factor-kappa B(NF-κB) and its relationship with tumor angiogenesis, cancer cell proliferation, invasion and metastasis in cervical cancer.Methods Immunohistochemical methods were adopted to examine the expressions of NF-κB/p65, microvascular density (MVD) labeled by CD34 protein and proliferating cell nuclear antigen( PCNA) in 115 cases with cervical cancer and 41 cases with normal cervical tissues.Results The protein expression rates of NF-KB/p65, MVD and PCNA in cervical cancers were significantly higher than in normal tissues, respectively(P<0.01). Over-expression of NF-κB/p65 in cervical cancers was related to lymph node metastasis and depth of invasion(P<0.05), but was not related to age, FIGO staging, histopathological type and differentiation degree(P>0.05). The expressions of MVD and PCNA were significantly higher in NF-κB/p65 positive tumors than in the negative ones (P <0.01).Conclusions (1) Positive expression of NF-κB/p65 protein was found in cervical cancers. (2) In cervical cancers,the protein expression rate of NF-κB/p65 was siginificantly higher than in normal tissues, NF-κB/p65 may play an important role in tumorgenesis. (3)Expressions of MVD and PCNA were closely related to NF-κB/p65, it may play an important role in tumor angiogenesis and cancer cell proliferation. (4) Over-expression of NF-κB/p65 was related to lymph node metastasis and depth of invasion, it may be related to cancer cell invasion and metastasis. (5)Detection expression of NF-κB/p65 may be of value in further understanding the biological behavior of cervical carcinoma, NF-κB/p65 is likely to be a target molecule in clinical therapy.