The Association Between Brain Natriuretic Peptide, High Sensitive C-reative Protein And Leptein(a) In Patient With Acute Coronary Syndrome

Object: This study addressed tomeasure serum B-type natriuretic peptide (BNP), high-sensitive C-reactive protein(hs-CRP)and leptein (a) concentration in patients with acute coronary syndrome, stable angina pectoris and normal healthy subjects, and aims to investigate the correlation of between BNP and acute coronary syndrome, and the clinical significance.Methods: one hundred and ninety subjects were divided into four groups: 36 patients with acute myocardial infarction, 38 patients with unstable angina;30 patients with stable angina, and 30 normal healthy subjects who were matched with age and sex as control.serum BNP concentration was determined by enzyme linked immuno-asorbent assay method and echocardiography was performed in all patients with coronary artery disease to detect left ventricular ejection fraction (LEVF), left ventricular volume parameters and to evaluate ventricular wall-motion, All data was analyzed with SPSS 10.0 statistical software;Numerical data was reported as the median value t standard deviation;Significant test uses t test;Correlation test uses multi-variate/stepwise regression analysis;probability value was considered significant when <0.05.Results1 The level of serum BNP concentration was increased in patients with acute myocardial infarction (391.13 ± 135.88) ng/L compared with those of unstable angina(267.11 ±80.22) ng/L, stable angina ( 36.47 ± 20.88)ng/ L and control subjects(32.87 ± 14.54) ng/L, P<0.05, respectively.2 The serum level of hs-CRP was higher in acute myocardial infarction patients (16.02± 14.97) mg/lthan those of unstable angina patients (10.89 + 6.65) mg/land stable angina patients(2.34±1.02) mg/1 and control subjects( (1.01+0.36) mg/1 , (P<0.01) .The serum level of hs-CRP in unstable angina patients was higher than those of stable angina patients and controlsubjects (PO.01) . The serum level of hs-CRP in stable angina was higher than those of control subjects (PO.01) .3.The serum level of LP (a) was higher in acute myocardial infarction patients (367.36 ±191.35) mg/1 than those of stable angina patients(190.80 + 130.12)mg/l and control subjects(150.09± 116.25)mg/I , (PO.01) .The serum level of LP(a) in unstable angina patients was higher than those of stable angina patients and control subjects (PO.01) .4 LVEF was decreased, left ventricular end diastolic volume (LVEDV), left ventricular end systolic volume (LVES V), were higher in patients acute coronary syndrome compared with those of stable angina and normal contrals, PO.05.5 After multi-variate regression analysis, se rum BNP concentration were positive correlated with hs-CRP ,LP (a) (r=0.53,0.54P<0.001).and concentration of hs-CRP and LP (a) were positive and significantly correlated with BNP (p'O.33O> 0.394, P <0.05)Conclusion Serum BNP concentration was increased significantly in patients with acute coronary syndrome, and the result suggested that BNP might be a useful risk marker for patients with acute coronary syndrome;moreover, BNP concentration was correlated with hs-CRP ,LP(a),and was independent with LVEF > LVEDV and LVESV for patient with acute coronary syndrome;...