Clinical Analysis Of 241 Early Syphilis

Syphilis is a frequently diagnosed sexually transmitted disease(STD), caused by treponema pallidum. Penicillin is the preferredmedicine for syphilis, but it has localization, for example, the patientmust do skin test to avoid allergic reaction. Medcine workers arelooking for a kind of medicine instead of penicillin for syphilis. Therewere reports of rocephin, azithromycin, roxithromycin, clarithromycinto cure syphilis, but curative effects are different, indeed the defeatedreports. In order to discuss the therapy protocol for syphilis, weanalyzed retrospectively clinical data of 241 cases in patients from2002 to 2004. The ratio of male to female is 0.85 in 241 patients (111males, 130 females). The ratio of male to female is 2.26 in 62 primarysyphilis patients (43 males, 19 females). The ratio of male to female is0.58 in 128 secdonary syphilis patients (47 males, 81 females). Theratio of male to female is 0.7 in 51 early latent syphilis patients (21males, 30 females). 202 cases were married. 39 cases were unmarried.The smallest was 17 years old. The oldest was 80 years old. Theaverage age was 37.5 years old. The course of disease was from 3days to 1.5 years. Clinical representation: chancre was symptom ofprimary syphilis, 5 cases going with inguinal lymphadenectasis. Therewere 128 cases in secondary syphilis. 32 cases reprented palmarisetplantaris syphilid. 30 cases represented mucular syphilid. 6 casesreprented papular syphilid. 4cases reprented syphilitic. 1 casereprented mucous membrane anthema.27 cases reprented more thantwo kinds of lesion at one time. 51 cases latent syphilis were found byphysical examination. These patients were classified into two groupsby treatment method: 131 cases were treated with penicillin Gbenzathine.110 cases were treated with cefixime. Record parametersof two groups of patients respectively, these parameters includedisappeared time of clinical symptoms, ill response and serology RPRnegative time. The difference between two groups was analyzed by X 2-test.Results: 1. A group of patient's clinical symptom disappeared in35 days. Chancre disappeared in 5 days in average. Skin lesiondisappeared in 30 days in average. B group of patient's clinicalsymptom disappeared in 30 days. Chancre disappeared in 4 days inaverage. Skin lesion disappeared in 28 days in average. There was norecrudescence.2. The differences were not significant about serology RPRnegative rate at 3rd month, 6th month and 12th month between twogroups (P>0.05). The total effective rate was 100%.3. The differences were greatly significant about serology RPRnegative rate at 3rd month and 6th month between latent syphilis andearly delomorphic syphilis(P<0.01).4. 15 patients'RPR test were still positive at 12th month betweentwo groups respectively. They both were old persons, long time orhigh RPR.Conclusion: 1. Serology RPR before treatment were lower, thetime was shorter, negative rate was higher.2. Negative rate of RPR of early delomorphic syphilis was higherthan latent syphilis after treatment in 6 months.3. The differences, about curative effect of early syphilis, werenot significant between penicillin G benzathine and cefixime.Therefore cefixime can be instead of penicillin G benzathine to thosewho are allergic to penicillin.