The Study Of Distribute Regulation Of TCM Symptom-sign In Chronic Renal Failure Patients

ObjectiveTo explore the distribute regulation of TCM symptom-sign in chronic renal failure patients, and the regulation of syndrome differentiation of compound symptom-sign which match TCM clinic practice .Then apply reference frame for clinical and basal study of CRF. MethodsOn the foundation which checks related articles and books extensively, combines the authoritative CRF d syndrome differentiation certificate of present stage, and ask for expert s ' opinions, design "the investigate form for CRF symptom-sign of TCM ". According to the diagnosis standard, 204 CRF patients were brought into the study. Then we collected the patients' symptom-sign of TCM. Ask for help of covariance software of the SPSS11.0, firstly use frequency to analysis main composing factors ' concretely distribution of each kind of syndrome from the one dimensional level. Then use K-means cluster method to classify constitute factors of the characteristic syndrome for the CRF patients, namely according to the syndrome content characteristics of each case to divide the categories. Thus divide the clinical compound syndrome types. Use Hiearchical cluster method to classify the syndrome differentiation factors of each compound syndrome type, find out index of four examination techniques which match each clinic compound syndrome type as the basis of syndrome differentiation. ResultsThe frequency analysis shows that deficiency of QI of the spleen and kidney is the majority type (72 cases, covered35.8%), and have a reduce trend gradually from compensatory phase to uremia;insufficiency of both QI and YIN also has a higher occurrence (50 cases, covered 24. 5%), and distribute in eachphase more even, but less in uremia period;deficiency of YANG of the spleen and kidney increase gradually from compensatory phase to uremia;deficiency of YIN of the Liver and kidney has lowest occurrence (15 cases, covered 7. 4%), and have a reduce trend gradually from compensatory phase to uremia;insufficiency of both YIN and YANG almost have no in compensatory and discompensatory phase, but expect to increase obviously in uremia (20cases, covered 34.5%). Blood stasis syndrome has the highest occurrence (157cases, covered77%), and increase gradually from compensatory phase to uremia;Water-pathogen syndrome is second (120 cases, covered 58.8%), water-pathogen syndrome, damp-heat syndrome distributes in each phase more even;The damp-muddy syndrome expects less in the compensatory phase , but increases gradually along with the kidney function decrease;The wind-pathogen syndrome less in compensatory and discompensatory phase, but expect to increase obviously in uremia (20 cases, covered 34. 5%). The damp-muddy syndrome often appears with deficiency of YANG of the spleen and kidney and insufficiency of both YIN and YANG(covered 51.4%, 65.5% respectively);The damp-heat syndrome, water-pathogen syndrome, blood stasis syndrome distribute more even in each deficiency syndrome;The wind-pathogen syndrome is mainly appeared in insufficiency of both YIN and YANG(covered 44.8%).K-means cluster method shows there are four clinical compound syndrome types: insufficiency of both QI and YIN, damp-heat and stasis syndrome;deficiency of QI of the spleen and kidney, water and stasis syndrome;deficiency of YANG of the spleen and kidney, damp-muddy .water and stasis syndrome;insufficiency of both YIN and YANG , damp-muddy .water and stasis syndrome. The main symptoms and signs of each clinical compound syndrome type as follows:Insufficiency of both QI and YIN, damp-heat and stasis syndrome : anorexia, lassitude in the loins and knees, shortness of breath and lazy to speak, sallow complexion, tiredness;insomnia and dreaminess, dry mouth, dysphoria with feverish sensation in chest , palms and soles, the stool is hard and dry, dry skin;bitter taste in the mouth .nausea and vomiting, the body trap heavy;numbness of limbs;The tongue is dark and with yellow coating, thready pulse or smooth pulse.Insufficiency of both QI and YIN, damp-heat and stasis syndrome: anorexia, pale complexion, shortness of breath and lazy to speak, lassitude in the loinsand knees;edama, the body trap heavy , The tongue is dark and with white coating, thready pulse.Deficiency of YANG of the spleen and kidney, damp-muddy .water and stasis syndrome: anorexia, shortness of breath and lazy to speak, lassitude in the loins and knees, tiredness;intolerance of cold, the waist cold and pain, pale complexion;edema, body traps heavy, nausea and vomiting, distension and fullness in the abdomen;pale and puffy tongue with white coating, thready and deep pulse.Insufficiency of both YIN and YANG , damp-muddy .water and stasis syndrome: shortness of breath and lazy to speak, lassitude in the loins and knees, tiredness;intolerance of cold;dysphoria with feverish sensation in chest , palms and soles, dry skin;nausea and vomiting, the body trap heavy, distension and fullness in the abdomen;edema, short of urine;dark face;The tongue is dark and with white coating, thready and deep pulse. ConclusionDeficiency of QI of the spleen and kidney, insufficiency of both QI and YIN, blood stasis syndrome, water-pathogen syndrome are most often occurrence in CRF patients;QI deficiency, blood stasis , water-pathogen is basic pathogenesis of CRF.There are four clinical compound syndrome types: insufficiency of both QI and YIN, damp-heat and stasis syndrome;deficiency of QI of the spleen and kidney, water and stasis syndrome;deficiency of YANG of the spleen and kidney, damp-muddy .water and stasis syndrome;insufficiency of both YIN and YANG , damp-muddy .water and stasis syndrome.