The Study Of Distributed Regularity Of Traditelnal Chinese Medical Syndrome In Pakinson Disease

Backguound and purposes:Parkinson Disease is degenerative disease in nervous system , that is charactered for denaturalization of dopaminergic neurons in substantia nigra and form of lewy body, popular with middle aged and elderly people. The crowd over 65 years of age falls ill a rate to 1000/100,000. Up to now .there is no good measure to cure PD . once in sickness, He or she should be invalided for life. By now, the use of drug is the major treatment, and the use of dopamine is the golden standard for this disease. Substitution therapy have certain curative effect and could improve symptom. But Substitution therapy couldn' t prevent development of the disease. And after the long-term apply, it will produce curative effect decrease and serious bad respond easily. But the clinical curative effect stay in further research. Surgery treatment includes pallidotomy, carving thalamencephalon and deep brain stimulation(DBS). With the improvement of solid directional technology and effect of operation, the bad responds are decreasing. But there are uncertainty in long-term curative effect and high cost. Gene therapy is an exciting study, but it is difficult to put in practice in clinic.TCM has the theory to treat the patient according to syndromes and is good at treating such relapsed easily disease. Currently typing according to syndrome differentiation of PD is not unified. Though there has been the standard which mainly come from the discussion and collective researches If parts of home experts, and is short of the clinical Epidemioloy of TCM pathogenisis, baffling its canonical treating according to the syndromes at ceratine effect of TCM.This research adopt the way of combining the epidemiological study and the strict modern statistics method, which tries to find the main syndrome of PD, the distribution If them and relativity between them and the part correlative result of checking. Participant:100 consistent cases who see doctors to the GuangDong Provincial Hospital of TCM and be diagnosed with PD during May 2005 to March 2006. Methods:Firstly, we designed the Investigation Format of TCM on the basis of the related articles and books. Secondly, we just investigated PD patients and make records carefully. Thirdly we Input and check the investigated data adopting the SPSS 10.0, and establish chronic gastrition measuring form, whose sensitivity and specificity are validated by experts, of basic syndromes of TCM on PD for computer using on the foundation of reading many articles, combining three presently relatively authoritative syndrome differentiation reference standards of TCM pathogenesision on PD, then getting the basic syndrome of every case through differentiation of syndrome adopting the calculator. Lately the statistics method involved are the descriptive method, the Hiearchical Cluster method, multidimensional scaling analysis and correlating analysis. Results:About the basic PD syndrome are deficiency of yin-blood syndrome (54 cases, covered 54%), deficiency of qi-blood syndrome(51 cases, covered 51%), deficiency of shen-jing syndrome (38 cases, covered 38%), deficiency of sui-hai syndrome(37 cases, covered 54%), According to frepuencies analysis. Synthetizing hierarchical clustering and multidimensional scaling analysis, deficiency of yin and wind-move is the basic pathogenesis of PD, there are four most familiar basic syndromes including deficiency of yin-blood syndrome, movement of wind-yang syndrome, deficiency of qi-blood syndrome, deficiency of shen-jing syndrome, All of them are familiar syndromes of PD together with deficiency of sui-hai syndrome and phlegm-heat wind-movement syndrome.According to results of the Hierachical Cluster method, we find that four primary clinic syndromes are deficiency of yin-blood and movement of wind-yang syndrome, deficiency of qi-blood and deficiency of sui-hai syndrome, deficiency of shen-jing syndrome, phlegm-heat wind-movement syndrome.The common symptoms of four syndromes are as follows:1. slowly movement, detain body, thirsty, dry stool, stringy and thin pulse (All of them are the sign of 'deficiency of yin-blood syndrome' .). paralysis, worry and angry , red tongue, quick and thin pulse((All of them are the sign of 'movement of wind-yang syndrome' ).2. deficiency of shen-jing syndrome: slowly movement, detain body, thirsty, paralysis, difficult urine evacuating, feeling of incomplete and difficult when stool evacuated, pale and red tongue, deficiency of coating of the tongue, deep and thin pulse.3. deficiency of qi-blood and deficiency of sui-hai syndrome: lowly movement, detain body, thirsty, paralysis, pale face, out of condition, impaired appetite, loose stool, pale tongue, deficiency of coating of the tongue, deep and thin pulse, slowly and week pulse.4. phlegm-heat wind-movement syndrome: thirsty, paralysis, high voice and great breath, worry and angry easily, much phlegm, insomnia, red tongue and glossy coating If the tongue, strong and stringy pulse. Conclusions:The basic pathogenesis of PD is deficiency of yin and wind-move. The basic PD syndrome are deficiency of yin-blood syndrome, movement of wind-yang syndrome, deficiency of qi-blood syndrome, deficiency of shen-jing syndrome. All of them are familiar syndromes of PD together with deficiency of sui-hai syndrome and phlegm-heat wind-movement syndrome. The four primary clinic syndromes are deficiency of yin-blood and movement of wind-yang syndrome, deficiency of qi-blood and deficiency of sui-hai syndrome, deficiency of shen-jing syndrome, phlegm-heat wind-movement syndrome.