Research On Pharmacodynamics Of Nanglixiao Capsule On Cerebral Cysticercosis

Cerebral cysticercosis is a kind of common and serious nervous system parasitic disease which the rate of deformity and mortality are so high as to harm people health seriously. The compounded Chinese medicine NangLiXiao comprise Omphalia, Corydalis tuber, Psoralea fruit, Astragalus root, Red sage root, Diding etcetera. It has been used effectively in clinic. For further discussing its function and mechanism, This article has conducted the correlative pharmacodynamics experimental study.Objective: To discuss the function and mechanism of NangLiXiao on treating cerebral cysticercosis and provide the experimental basis for the clinical treatment.Methods: Adopting pig bile culture medium, the inhibiting or killing effects on pig bladder worm in vitro were observed;by using the methods of xylene-induced ear inflammation in mice and granuloma swelling induced by cotton ball in rats, the effects of anti-inflammation were observed;by using the methods of body twisting and hot-plate in mice, the effects of analgesia were observed. Through the mice auricle microcycle, the rats thrombus law in vitro and bleeding time, clotting time determination to the mice, the function of invigorating the blood were observed;adopting the penicillin abdominal cavity injection method, the mice epilepsy model were prepared, and epilepsy mice brain organization MDA content and SOD, ATPase vigor be measured by using chemical colorimetry.Results: The data indicated after statistics processing: NangLiXiao has the inhibiting action of bladder worm in vitro;it can inhibit the mice auricle tumefaction degree induced by xylene and the rats granuloma swelling induced by cotton ball;it hasanalgesic effects on mice in writhing test and hot plat test;it can expand the caliber of arteriole and venule, increase the open numbers of capillary vessel, prolong the bleeding and clotting time and reduce length and weight of rat's thrombus;it can reduce the MDA content but enhance SOD, ATPase in epilepsy mice brain organization.Conclusions: NangLiXiao has the effect on restraining pig bladder worm, anti-inflammation, easing pain, activating blood circulation to dissipate blood stasis, anti-epilepsy.