Association Between The Gene Polymorphisms Of Platelet Membrane Glycoprotein Ibα And Cerebral Infarction

Background and purpose Platelets play an important role in the development of arterial thrombosis. These events are mediated through the combination of platelet membrane glycoproteins (GPs) with von Willebrand Factor (vWF). This combination can produce powerful signal which will result in platelet activation and aggregation. Eventually, the arterial thrombosis would be formed . Platelets in advanced stenosis artery can be activated and aggregated by the binding of an adhesive ligand vWF to the GPIb-IX-V complex under high shear stress without chemical agonists. The platelet glycoprotein receptor Ib α have three gene polymorphisms: VNTR, Kozak and HPA-2 gene polymorphisms. The polymorphisms of platelet glycoprotein receptor Ib α can alter its alloantigen system, changing its structure, and increasing the amounts of GPIb α expressing on the platelet surface, as well as extending the GP Ib binding sites for vWF and increasing the avidity between them, accordingly impacting on platelets adhesion, aggregation, activation and thrombus formation. This study is to investigate the distribution of genotypes and alleles of GPIb α VNTR, Kozak and HPA-2 gene polymorphisms in Chinese population and the correlation between these polymorphisms and cerebral infarction.Methods A Chinese hospital-based case-control study was conducted with 119 cases of acute cerebral infarction and 166 controls whose age and sex proportion matched...