FHIT Gene And PCNA Expression In Human Gastric Carcinoma

[Background and Objective]Gastric carcinoma is a very common tumor in China, both its incidence rate and mortality occupy the first place among the gastrointestinal malignant tumors. Gastric carcinoma is a severe threat to peoples health, but its pathogenesis remains unilluminated. Modern molecular biology indicates cancer is developed by multi-gene alterations, so exploring possible relation between some gene proteins and oncogenesis or progression of gastric carcinoma becomes hot spot. The fragile histidine triad (FHIT) gene is located at the FRA3B site of chromosome 3p14.2, it has recently been proposed as a tumor suppressor gene. FHIT gene deletions or aberrant transcripts have been identified in a variety of human malignancies, including gastric carcinomas, suggesting that FHIT gene may play a key role in tumor development. Proliferating cell nuclear antigen (PCNA) is a 34 KDa nuclear protein and acts as a cofactor of DNA polymerase 8 in DNA synthesis in S phase of the cell cycle. As an index of cellular proliferative status, the overexpression of PCNA with high frequency was usually used as a reliable marker for assessment of tumor progression, and clinical prognosis of patients with various malignancies. Our purpose was to investigate the expression of Fhit protein and PCNA in gastric carcinoma and their relationship to clinicopathologic factors. [Methods]We studied the expression of Fhit protein and PCNA in 116 cases of gastric...