Comparison Of The Therapeutic Effect Of Three Drugs By Bladder Instillation After Transurethral Resection Of Superficial Bladder Cancer

Objective:To compare the therapeutic effect and safety of (THP), Hydroxycamptothecin (HCPT) and Mitomycin C(MMC) by bladder instillation after transurethral resection of superficial bladder cancer. Methods: 130 patients of superficial bladder cancer after transurethral vesection were divided into three groups randomly. THP by bladder instillation was used in the first group, HCPT in the second group and MMC in the third. The effects were observed. Results: All patients were followed up 24 months. The tumor recurrent rate in THP group, HCPT group and MMC group were 16.67%(8/48), 17.07%(7/41),36.59%(15/41), respectively. The effect of THP and HCPT is superior to MMC, compared with the two drugs. The tumor recurrent rate of the Pirarubicin and Hydroxycamptothecin groups differed significantly between the Mitomycin group, P<0.05. Conclusions: HCPT has low side effect,better tolerated and tetten effect so it is the first choice in clinical bladder instillation. Intravesical instillation of THP for patients after transurethral resection of superficial bladder cancer could decrease tumor recurrent rate,prolong the tumor-free survival period.