Expression Of Endostatin,VEGF Protein In Endometrial Carcinoma And Their Relationship To Angiogenesis

Objective:To investigate the expression of Endostatin, VEGF (Vascular endothelial growth factor ) protein in endometrial carcinoma and their relationship to angiogenesis.Methods:The expression of Endostatin and VEGF in the paraffin-embeded section of 65 cases of endometrial carcinoma and 26 cases of normal endometrium was evaluated by immunohistochemistry Maxvision technique. Microvessel density(MVD) of endometrial carcinoma and normal endometrium was also determined with anti-CD34 as the label. The relationship between expression of Endostatin , VEGF protein with the clinicopathological parameters and the expression of CD34 was analyzed.Results:1. The expression of Endostatin in endometrial carcinomaThe positive rate of Endostatin in endometrial carcinoma ( 86.36%,57/66) was higher than in normal endometrium (42.31%, 11/26) (p<0.000) , The level of expression of Endostatin in stage> II endometrial carcinoma was higher than in stage I endometrial carcinoma (p<0.05 ) but had no relation with the elements age,histological differentiation and the depth of invasion myometrium (P>0.05) .2. The VEGF protein in endometrial carcinomaThe positive rate of VEGF in endometrial carcinoma (83.33%,55/66) was higher than in normal endometrium (30.76%, 8/26) (p<0.000); The level of expression of VEGF was significantly associated with clinical stage (p<0.05) , histologic grade (p<0.05) and the presence of invasion to >l/2 myometrium (p<0.05) ,but had no relation with the age...