| Objecti: Elaeagnus Angustifolia Polysaccharide (EAP) is a kind whichwithdraws from the narrow-leaved oleaster for beta -1,3 key Connection of water-soluble acidic polysaccharide, has the many kinds of biologiesactiveness. Day by day thorough along with the recent years plantpolysaccharide research, discovers some sugars compound and manybiological phenomena and the disease close correlation. Thepolysaccharide most early took the medicine was in 1943, after the20th century 60's the polysaccharide took one kind of ideal immunityconditioner has aroused people's widespread interest. The research indicated that, The polysaccharide has the anti-oxidation, the anti- infection, the anti- radiation and falls theblood sugar, falls the blood fats and so on many kinds of biologiesactiveness. To Elaeagnus Angustifolia Polysaccharid researchdomestic, outside mainly pauses in the nutrition ingredient withdrawswith the physics and chemistry constant determination in, falls theresearch to it which the fat loses weight not yet to see the report. At present domestic and foreign all vigorously is developing newlyfalls the fat to lose weight the medicine, but Elaeagnus Angustifolia Polysaccharid also becomes the new research radiationdirection. This research observes Elaeagnus Angustifolia Polysaccharid through in vivo experiment to fall the fat to the bigmouse to lose weight and the anti- oxidation.Methods: The cholesterol content which the body weight for 180～220 g Wistar grown-up female and male big mouse, according to just bringsback when determines, stochastically divides into nine groups, eachgroup of 20 (female and male are half and half),respectively benormal comparison group, high fat model group, high fat narrow-leavedoleaster polysaccharide high, center, low three monitoring teams, thenormal Elaeagnus Angustifolia Polysaccharid is high, center, the lowthree monitoring teams, 5% feed group. Gao Zhizu gives Gao Zhigao the camp nourishment to feed, high fatfeed: : The ordinary feed joins 1% cholesterol, 10% lard, 0.1% cholicacid sodium. Raises 90d in 18-21℃ambient temperature with under80% humidity free potable water condition, in raising period throughgives Elaeagnus Angustifolia Polysaccharid to the tap water China and Canadamedicine the polysaccharide. Each 7d weighing animal body weight 1,and the regular recording (7d) each group of big mice drink the watervolume and take in food the quantity value, each 30d empty stomachpicks tail blood, carries on the related determination.By 722 spectrophotometers, determines the blood serum with the enzymecolor method triglyceride (TG), Cholesterol Kit (CHO), the highdensity lipoprotein cholesterol (HDL-C), the low density lipoproteincholesterol (LDL-C), the total anti- oxidized ability (T-AOC), super oxidedismutase (SOD) and the MDA content. The experimental result ( x_±s) indicated by the mean value±standarddifference that, uses the variance analysis to carry on many samplesmean value 2 vs 2 comparisons.Result:The experimental laststage Elaeagnus Angustifolia Polysaccharid various monitoring teams and the comparison groupcompares, the body weight increases heavily has the enhancement, butincreases heavily by Gao Zhizu is most obvious (P﹤0.05),; Eats foodthe quantity change not to be big, basically tends to the balance.Big mouse blood serum TG, CHO, the LDL-C experimental result showedthat, Elaeagnus Angustifolia Polysaccharide various monitoringteams are lower than the comparison group (P﹤0.05), but the HDL-Ccontent elevates, the ratio is higher than the comparison group(P﹤0.05).Big mouse blood serum T-AOC, the SOD active level and the comparisongroup compare, Elaeagnus Angustifolia Polysaccharide variousmonitoring teams have elevate (P﹤0.05); In the MDA contentcomparison, Elaeagnus Angustifolia Polysaccharide variousmonitoring teams are lower than the comparison group (P﹤0.05).Conclusion: Elaeagnus Angustifolia Polysaccharide may effectively reduce CHO,TG, the LDL-C level, enhances HDL-C the level; And in eats food thequantity to tend to in the balance situation, effectively reduces theanimal body weight. Indicated Elaeagnus Angustifolia Polysaccharide has reduces the blood fats, the improvement lipinmetabolism disorder, in does not suppress the function which under theappetite effectively loses weight. Elaeagnus Angustifolia Polysaccharide elevates experimental animalblood serum T-AOC, the SOD level, reduces MDA the content, indicated Elaeagnus Angustifolia Polysaccharide can enhance the organism theanti- oxidized ability, slows down the lipin peroxide the productionand/or the acceleration peroxide elimination. Elaeagnus Angustifolia Polysaccharide affects and eliminatesthefree radical to the high blood fats and the anti- oxidizedintervention, the anti- oxidized ability and so on concerns.Believed according to this findings that, Elaeagnus Angustifolia Polysaccharide has good prevents disease the health care effect,hopefully becomes one kind quite to have the development prospect thehealthy product.This experimental result may provides the scientific basis for thenarrow-leaved oleaster polysaccharide in the health foods and themedicine domain application.
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