The Relationship Between TCM Differentiation Syndromes Of Type 2 Diabetes Mellitus And C-Reative Protein & Lipid Metabolic Disturbance

Background: The occurrence and development of Type 2 diabetes mellitus has closely related to low grade inflammation.The vasculopathy of Type 2 diabetes mellitus was caused by the factor such as high blood sugar,hypertension, high blood lipid,high blood stickness and so on,but lipid metabolic disturbance rose more importance function than other factors.Objective: To provide objective evidence for the judgement of TCM's syndromes and clinical idea for the precaution and treament for T2DM and its complication by observing the relationship between the TCM syndromes and c-reative protein.Materials and methods: According to WHO diagnosis criteria and TCM differentiation criteria, 101 cases were selected,and they were divided into 5 groups. Yin deficiency and heat excess syndrome (YDHES):24cases(11male,13 female), the average age was 54.41±6.32 years old; Qi and Yin deficiency syndrome (QYDS):31 cases(14 male,17 female), the average age was 55.32±6.67 years old; Moist Heat deficiency syndrome (MHDS):21 cases(9 male,12 female), the average age was 55.04±7.03 years old;Stagnated blood deficiency syndrome(SBDS): 18 cases (11 male,7 female), the average age was 55.72±4.67 years old ;Yin and Yang deficiency syndrome (YYDS):7 cases(3 male,4 female), the average age was 55.85±6.73 years old. Healthy people (17 male and 14 female) were taken as the control group, the average age was 55.85±6.73 years old. Then detected CRP by Elisa;triglyceride (TG),high density lipoprotein-cholestcrol (HDL-C) and Total cholesterol(TC) by zymology; glycosylated hemoglobin(HbAiC) by microclumu chromatography ; fasting plasma glucose (FPG) by glucose oxidase.And measure blood presure in morning. Results: 1. Under the premise that keeping the age ,blood pressures of 4 TCM Differention Syndromes with out comparation(YYDS was not in the discussion because its cases is too few):(1).The degree of HbA₁C is as follow: SBDS〉MHDS〉QYDS,YDHES; (2)â‘ . The degree of TG,TC,LDL are as follows: SBDS, MHDS〉QYDS〉YDHES;â‘¡. The degree of HDL is as follow: YDHES,QYDS〉SBDS,MHDS. 2. The level of CRP is closely positive correlated to TG,TC,LDL and negative correalated to HDL,but not correlated to HbA₁C.Conclusion: The higher of the degree of Type 2 Diabetes' moist heat and stagnated blood,the more serious of lipid metabolic disturbance and inflamation.