Clinical Significance And Expressions Of Survivin In Cervical Carcinoma

Cervical cancer is one of gynecology department common malignant tumors, cervical cancer's pathogenesis is complex, at present still not completely clear, but the existing research indicated that cervical cancer's occurrence, the development are from the cervix of the uterus atypical proliferation (lightly to heavy), the preinvasive carcinoma, the early infiltration cancer, the infiltration cancer's continual developing process, it is a polygenes participation multi-step complex process, damps the cancer gene function forfeit with the cancer gene expression is his/her the cell cancer molecular foundation. The cell proliferation and perishes weakly balanced is advantageous to the human body inner rim boundary stability, once is balanced is broken, the cell perishes weakly is suppressed, causes the cell excessive proliferation, the variation cell not to be able independent to perish weakly causes the tumor the occurrence. After the cell perishes is weakly cell's some kind of token stimulus one kind of driving cell"the suicide"the withering away process, the tumor occurrence is the cell multiplication and perishes weakly the balanced being out of balance result, in the tumor occurrence development is main negative regulative function. The cell perishes weakly the signal transmission disorder namely the process which perishes weakly for the influence cell, is also the important mechanism which the tumor forms, but the cell perished weakly suppresses has broken the cell proliferation and cell death balanced. Tumor occurrence, because on the one hand tumour cell excessive proliferation, on the other hand is because the cell death is blocked result, therefore, perishes weakly from the cell the angle, the tumor occurrence is not the cell proliferation has been too quick, but was the cell death has been too slow, could not carry on the result which normally the death eliminated. In recent years had discovered the survivin gene is one kind perishes the suppressor gene, the survivin main biology function is weakly suppresses perishes weakly, is the present known function strongest perishes weakly suppresses the protein. Survivin causes the cell to perish weakly mainly has two ways: The death acceptor way and the line plastochondria way, its result finally causes the cell through the activation downstream effect factor to perish weakly, the direct adherency in the activation effect factor, enables it to play the role, thus blocks the cell to perish weakly the process. The Survivin expression has highly the specificity, it basic does not express or the expression finally in the normal adult end differentiation organization declines, but only in embryo and in nearly all tumor organization high expression, therefore may take the new tumor member symbol. Survivin has the expression in the nearly all human body malignant tumor, with the tumor occurrence, the development and the prognosis is closely related, is the cell perishes weakly in the inhibitory process the essential protein. Perishes weakly the suppressor gene Survivin excessive expression or expresses in cervical cancer's occurrence development as if is playing the vital role. Because Survivin basic does not express or the expression in the Normal tissue declines, before it possibly is cervical cancer's cancer, the pathological change and the cancer early time symbolized, and is playing the influential role in cervical cancer's progress. the survivin gene in the pathological change in the process which evolves to the carcinoma of cervix has the influential role before the cervical cancer, with carcinoma of cervix patient's lymph shift remarkable related, but carcinoma of cervix by stages and survivin gene expression one of for independent prognosis influencing factors. This article through before the normal cervix of the uterus, cervical cancer the pathological change, the preinvasive carcinoma, the cervix of the uterus infiltration cancer's survivin gene expression, will discuss it in the cervix of the uterus carcinogenesis, the development function and the clinical significance, and judges cervical cancer's malignant degree and the prognosis. Because moreover the survivin gene induction cell produces perishes weakly, will treat cervical cancer for the future gene level to provide the new mentality. Before using the SP immunity histochemical method to examine 83 example cervical cancers, 30 example normal cervixes of the uterus, 105 example cervical cancer, the pathological change, 48 example preinvasive carcinomas, 35 example cervix of the uterus infiltration cancer to organize the survivin gene expression, all cervical cancer specimen elects before the technique not after the chemotherapy, the radiotherapy, and does not have the naked eye obvious necrosis's organization. After the experiment, obtains the following result: In the normal cervix of the uterus organization the survivin protein does not have the expression, the cervix of the uterus preinvasive carcinoma organizes the survivin protein masculine gender expression rate is 35.4%; In the tumor organization the survivin protein masculine gender expression rate is 62.8%; survivin in the normal cervix, cervix of the uterus CINI, cervix of the uterus CINII, in the cervix of the uterus CIN III, carcinoma of cervix's expression difference has statistics significance, along with pathological change's development,the survivin expression strengthens(P<0.05)。The Survivin protein masculine gender expression rate has the lymph node shift is 75.0%(21/28),the non-lymph shift is 46.2%(6/15), P<0.05;the pathology I issue is by stages the 50.0%(9/18), II time is 72.0%(18/25), P<0.05;along with clinical increases and the lymph node shift by stages, the protein masculine gender expression rate elevates gradually, P<0.05。Survivin does not express in the normal cervix of the uterus organization, expresses the masculine gender rate in the cervix of the uterus cancer process to elevate gradually, the Survivin expression masculine gender rate and cervical cancer's organization graduation degree and clinical present by stages related, the Survivin gene expression has the early time which transforms in cervical cancer malignancy, and has provided the valuable judgment target for cervical cancer prognosis. Between Survivin and cervical cancer's close relation, in the prognosis aspect, the clinical related research confirmed between Survivin and cervical cancer's close relation, the Survivin masculine gender means disease recrudescence the risk is high, patient's malignant degree increases, the life reduces, the bad prognosis, needs to strengthen the revisit. In summary, survivin does not express in the normal cervix of the uterus organization, cervical cancer organizes the high expression, and in the normal cervix of the uterus organization, the preinvasive carcinoma and the infiltration cancer the difference has the significance significance. Prompts survivin in the normal cervix of the uterus organization's unusual expression and cervix CIN and carcinoma of cervix's occurrence, the development close related, moreover, in cervix CIN transforms to the carcinoma of cervix in the process has played the strong character, may take the early cervical cancer's auxiliary diagnosis target, provides the basis for the clinical judgment cervix of the uterus metastasis and the pathology, survivin gene expression it possibly is by stages affects cervical cancer prognosis the important molecular target, its expression indicates that the carcinoma of cervix patient has the bad prognosis, the target may promote the tumour cell to the Survivin treatment to perish weakly and to suppress its multiplication, but does not have the adverse effect nearly to the Normal tissue, this is the target to the Survivin treatment unique merit. May affirm, if will obtain the counter-righteousness medicine and the traditional chemotherapy drug synergism the good clinical care effect, will treat cervical cancer for the future gene level to provide the new mentality.