Clinical Analysis On Idiopathic Focal Segmental Glomerulosclerosis Treated By Supplementing Qi And Activating Blood Circulation Method

Objectives:Through the treatment by Chinese herbs of supplementing Qi and activating blood Circulation of idiopathic focal segmental glomerular sclerosis(FSGS), to investigate of the Relationship between the Syndrome Patterns in TCM Differential Diagnostics and the pathological types of FSGS。Through the analysis of Clinical symptoms before and after the treatment the changes, biochemical changes in blood,we evaluated whether the oral liquid of Tongmai exists protective effect of FSGS primary types of chronic kidney disease。At the same time we have the initial observation of distribution of TCM syndromes for idiopathic focal segmental glomerulosclerosis,and judge Qi deficiency and blood stasis type of the proportion of FSGS。Method:1.In this study,30 cases of renal biopsy diagnosed as idiopathic FSGS in a dialectical analysis of TCM,symptom questionnaire filled out,and then given to the role of Tongmai of supplementing Qi and activating blood circulation a tid Oral Liquid,treatment Eight weeks.2.Observe their symptoms before treatment,and judge qi deficiency and blood stasis type in the proportion of patients with FSGS。Then filled out before and after treatment in patients with the points of qi deficiency and blood stasis.4.Testing before and after treatment 24 h urine protein,urinary malformed red blood cell count,blood albumin,hemoglobin,serum creatinine and blood urea nitrogen,blood cholesterol and triglyceride,high-density lipoprotein, LDL and coagulation,urine PDF.Results:1.The points of Qi deficiency and Blood stasis after treatment in patients with Tongmai Oral Solution than before significantly reduced(P＜0.05), prompt treatment through Tongmai Oral Solution reduce idiopathic FSGS patients with symptoms of Qi deficiency and blood stasis.2.The study suggested that the quantitative of ptoteinuria in 24 hour were significantly decreased(P＜0.05)after the treatment than before,prompted the treatment Tongmai oral solution may be reduce proteinuria of idiopathic FSGS patients.Before and after the treatment of urinary malformed red blood cell count were no significant difference,there is no evidence prompted the treatment of Tongmai oral solution may be reduce idiopathic FSGS patients to the role of hematuria.3.Serum albumin compared before and after treatment were significantly increased,suggesting that Tongmai oral solution for patients with FSGS may promote albumin synthesis,but its role may also be achieved by reducing proteinuria,Its increased serum albumin mechanism to be further elaborated. Hemoglobin before and after the treatment showed no significant difference (P＞0.05),prompted Tongmai oral solution in the short term treatment of hemoglobin no significant impact,but clinical data analysis,research in patients with anemia only for four people(13%),But were mild anemia,is whether its for its role in improving the anemia could not be ascertained. Two groups of blood urea nitrogen and serum creatinine before and after the treatment showed no significant difference(P＞0.05),suggesting that Tongmai oral solution in the short term treatment may protect kidney function.4.After the treatment the cholesterol,low-density lipoprotein dropped significantly,and the high-density lipoprotein marked increase. triglycerides after the treatment showed no significant difference(P＞0.05). This study suggested that Tongmai oral solution for patients to adjust FSGS lipid metabolism,and by improving patients with abnormal blood lipids,may have the protection of kidney function.5.There were no significant difference in the concentration of the blood PT and APTT between pre- and post- treatment,but significant difference in the concentration of blood Fg and urine FDP。It prompted that Tongmai oral solution improve hypercoagulability。Conclusion:1.Qi deficiency and blood stasis type existed in the majority of patients with FSGS.The points of Qi deficiency and Blood stasis before treatment further integration with the course was positively correlated.The points of Qi deficiency and Blood stasis after treatment in patients with Tongmai Oral Solution than before significantly reduced.2.The research suggested that the treatment with Tongmai Oral Solution may be reduce proteinuria in patients with FSGS,elevated blood albumin,improved lipid disorders and kidney and blood hypercoagulability,may have the protection of kidney function.