| Objective: To retrospectively analyze the clinical characteristics of the patients with Ulcerative Colitis (UC) in Dalian Medical University in recent years.Mothods: According to the diagnosis and treatment of Inflammatory Bowel Disease established by Digestive Branch of Chinese Medical Association in 2000, The clinical datas of 140 UC patients were collected retrospectively from Department of Gastroenterology of Dalian First Affiliated Hospital of Dalian Medical University between 2005 and 2007 were studied.Results:1.General Data: The incidence of hospitalization for UC was 2.92% in 2005,2.97% in 2006 and 3.48% in 2007. 58 men, 82 women. The ratio of male to female was 1:1.4, the onset age was 13-82 years, the mean age was 44.14±16.56 years, the first peak age was between 30 and 49 years, the second peak age was between 60 and 69 years. Of 140 patients, 131 had diagnosed by endoscopy in the first time(131/140 93.6%).2 . Range Classfication: Of 140 patients, 33(23.6%) was procitis, 17(12.1%) was proctosigmoiditis, 15(10.7%) was left-sided colitis, 51(36.4%) was pancolitis and 24(17.1%)was regional colitis.3.Extent Classfication: 83(59.3%) patients met the criteria for mild type, 35(25.0%) met moderate and 22(15.7%) met severe severity. Of 140 patients, 133 (95%) was activity stage.4.Course Classfication: 57(40.7%) was initial type, 17(12.1%) was chronic permanent type, 65(46.4%)was chronic relapse type and 1(0.7%) was acute fulminant type. The most commonly reasons of recurrent mucopurulent is discontinuation or unregular therapy.5 . Clinical Findings:The major symptoms were diarrhea (97.1%), abdominal pain (75%) and bloody stool (75%).6.Manifestations of colonoscopy:①continuity and diffuse changes of lesions 82.6%,②mucosal hyperemia and edema, indistinct vasoganglion 96.4%,③multiple erosios or superficial ulcers 92.1%,④cohere purulent secretion 55%,⑤rise mucosal fragility and tend to haemorrhage 46.4%.7.Pathology: 28 patients had took pathologic examination in 140.①diffuse inflammatory cells and chronic inflammation in the colon 82.1%,②accrementition of cryptae 21.4%,③Inflammatory necrosis 17.9%,④erosios or superficial ulcers 14.3%;⑤Crypt abscess 3.6%.8.Lab Examination: Platelet count and albuminuria had different levels of abnormal rate in laboratory, mostly among moderate to severe severity. 22 had autoantibody test, 31.8% P-ANCA is positive, all UC's ASCA is negative.9.Extra-intestinal Manifestations (EIM): 21 patients had EIM in 140,11(52.4%)was moderate, 7(33.3%) was severe, male 13(61.9%).Their major manifestations are liver function damage (aminopherase step up,9.3%), adiposis hepatica(4.3%) and arthritis (2.9%).10 . Therapy: Treatment was 5-ASA combined retention. All these patients received the recommended treatment (including aminosalicylate and retention enteroclyster), and 94.6% patients responded well.Conclusion: The hospitalization for UC has been increased in recent years in Dalian Medical University. The first peak age was between 30 and 49 years, the second peak age was between 60 and 69 years. The typical clinical characteristics of UC are diarrhea, abdominal pain and bloody stool, mostly with mild to moderate severity, the lesions are commonly located in the rectum or rectosigmoid, the major types of UC are chronic relapsing and first onset with rare EIM, there was a tendency that EIM was more likely among patients in moderate to severe severity and was most commonly among male. Main diagnosis method is endoscopy. Laboratory markers are valuable in the evaluation of activity and severity of UC. Most patients respond well to the recommended treatment. |
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