| It's indicated by multiple researches on epidemiology that diabetes mellitus(DM) is correlated with periodontitis, although the interactional mechanism between DM and periodontitis is not quite clear. The host response, we can presume, may be influenced by DM. Hyperglycemia is one periodontitis predisposing factor. Many researches on serum from patients with DM display the the higher levels of some cytokines such as interleukin 1(IL-1), IL-6 and tumor necrosis factorα(TNF-α).Gingival crevicular fluid(GCF),from blood, infiltrated and excreted by local tissue and proteinum etc, contains many kinds of immune substance and molecules. As the infiltration of GCF is relevant to periodontitis, GCF has been taked as one extensively means to investigate periodontitis. Polymorphonuclear neutrophils(PMN) , more than 90% of all the immune cells in GCF, is the principal immune cell and plays a great role in immune response of periodontitis. Soluble intercellular adhesion molecule 1 (sICAM-1), belonging to the immunoglobulin superfamily, may contribute enormously to PMN adhering to vascular endothelial cell and immigration. It's reported that PMN of patients with type 2 DM shows dysfunction, concerned with greater mobility of periodontitis and worse attach level(AL). Through combination with its receptor lymphocyte function associated antigen 1(LFA-1), sICAM-1, produces a key effect on PMN adhesion and then amplify local immune response. Although there are still some controversies, GCF concentration of sICAM-1 from periodontitis patients is higher compared with that of healthy men is generally accepted. Scholars found GCF concentration of sICAM-1 from periodontitis patients degrade after experienced consummate treatment. We've retrievaled none source from MEDLINE about GCF concentration of sICAM-1 from people with type 2 DM. Whereas the conclusion through epidemiology, periodontitis with DM is quite difference with periodontitis without DM, which could cause greater mobility of periodontitis and worse alveolar bone absorption and AL. As a key factor effect on PMN adhesion, the GCF concentration of sICAM-1 from periodontitis with DM, we infer, may be differ from that of the healthy one.We intend to observe GCF concentration of sICAM-1, and to analyze the levels of sICAM-1 among periodontitis with DM, periodontitis without DM, controlled well DM without periodontal disease, and healthy people ,then try to study how DM influences periodontitis.Results as follows:1 GCF volumeWe use a ANOVA model. Two groups of Periodontitis have the higher GCF volume and the group of periodontitis without DM is higher than of peirodontitis with DM. There is no statistical difference between the two groups without periodontal disease.2 GCF concentration of sICAM-1We use a ANOVA model too. The group of periodontitis without DM have the highest concentration of sICAM-1. The group of periodontitis with DM have the lowest concentration of sICAM-1. There is no statistical difference between the two groups without periodontal disease.Conclusions: GCF concentration of sICAM-1 from the group of periodontitis patients with DM degrades markedly, even being lower than those from two control groups. sICAM-1 is probably hindranced when moving to GCF, or the expression of sICAM-1 may be inhibited by some substance. So, it's probable that not only inflammatory reaction, but also the interaction between periodontitis and DM, could change the GCF concentration of sICAM-1. Our research is just confined to the advanced periodontitis, in the different stages of periodontal inflammatory reaction, the GCF concentration of sICAM-1 need in-depth investigation, and it's necessary to research how the lower GCF concentration of sICAM-1 influences PMN.
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