The Clinical Observation Of Longchangkeli In The Treatment Of Benign Prostatic Hyperplasia And The Study Of BCL-2 Gene Expression

Objective:To investigate the Longchangkeli treatment of benign prostatic hyperplasia and the clinical efficacy of bcl-2 gene expression to explore the impact of particles on the treatment of retention of urine Chang mechanism of benign prostatic hyperplasia.Methods:80 cases of benign prostatic hyperplasia were randomly divided into two groups,treatment group,40 cases of oral Longchangkeli;40 cases of the control group,oral Longbishu,one month a course of treatment for the two groups are the treatment of 3 courses.Of clinical symptoms before and after treatment,IPSS,maximum urinary flow rate,residual urine volume,prostate volume,such as comparative analysis of indicators.Some experiments using rats injected testosterone propionate after castration-induced prostatic hyperplasia law model,after oral administration of 30d executed.Removal of prostate tissue wet weight was measured using two-step method of PV particles and infirmity infirmity closed Chang Shu intervention organizations prostatic hyperplasia in rats bcl-2 gene testing.Resulsts:Clinical observation:In the treatment group,the total effective rate 78.4%.In the control group,the total effective rate was 64.7%.With X~2 test, the difference between the two groups significant(P＜0.05),which show that the effect of Longchangkeli is better than the control group in treatment.The experimental results show that wet weight of prostate:blank group 0.61±0.03; model group 0.95±0.04;Longbishu group 0.73±0.02;the low dose of Longchangkeli 0.80±0.05;the normal dose of Longchangkeli 0.78±0.07;the high dose of Longchangkeli 0.68±0.03;compared with model group P＜0.05. Prostate index:blank group 0.143±0.006;model group 0.226±0.008; Longbishu group 0.172±0.004;the low dose of Longchangkeli 0.199±0.012; the normal dose of Longchangkeli 0.181±0.010;the high dose of Longchangkeli 0.168±0.003;compared with model group P＜0.05.Expression effect study of Longchangkeli on prostate's bcl-2 in benign prostate hyperplasia rats(average optical density):blank group 0.089±0.010;model group 0.131±0.005;Longbishu group 0.093±0.015;the low dose of Longchangkeli 0.109±0.001;the normal dose of Longchangkeli 0.097±0.003; the high dose of Longchangkeli 0.091±0.003;compared with model group P＜0.05.Conclusion:1.The Longchangkeli can obviously alleviate the symptoms and signs of the BPH.The results show that the effect of Longchangkeli on the BPH was superior to that of Longbishu.2.Longchangkeli can effectively reduce the model of rat prostate wet weight,reduce the pathological changes.Its mechanism of rat prostate may be reduced bcl-2 gene expression in the promotion of prostate cell apoptosis.