Clinical Research Of Minor Decoction Of Bupleurum Add And Subtract Per Os Coordinating Foot Massage For Postprandial Distress Syndrome With Incoordination Between Liver And Stomach

BackgroudFunctional dyspepsia(FD) is a group of clinical syndromes which are caused by dysfunction of stomach and duodenum, eliminated organ diseases. FD was segmented into two subtypes which were postprandial distress syndrome and epigastric pain syndrome in Rome III criteria. FD is one of the most common functional gastrointestinal disorders, which has high morbidity, high recurrence rate, wide-span population and age. FD is becoming a key modern medical care problem, which impacts on the quality of life.The exact pathogenesis of FD has not yet completely clear, so it is lack of specific treamt. The protracted nature of treatment and side-effect of western medicine will bring enormous mental stress to patients. With the further study of classical prescription for FD, people will pay more attention to its efficacy.ObjectivesTo explore the effect and advantage of Minor Decoction of Bupleurum add and subtract per os coordinating foot massage for postprandial distress syndrome with incoordination between liver and stomach by observing quality of life and safety and discuss its mechanism.MethodsWe divided the cases that met the included criteria into 3 groups:treatment group, control groupâ… ,control groupâ…¡.There are 40 cases in each group. Control I was treated by decotion solution 200ml from Minor Decoction of Bupleurum add and subtract per os 30min ante cibum per morning and night while TG added its second decotion solution for low foot massage ante horam decubitus;control groupâ…¡for Mosapride 5 mg per os 30min ante cibum three times a day. A week before and during the treatment, promoting the gastric motility and other relevet medications are forbidden. Before and after the treatment, quality of life and syndromes improvement were used to evaluate by observing SF-36 scale and common syndromes scale;Likert's cumulative method was used in SF-36 scale.Results(1)Total efficiency:â‘ after the treatment, total efficiency was 90.00%; there were 8 cases with cure,9 cases with marked effect,19 cases with effect,4 cases with no-effect in treatment group. Total efficiency was 74.36%; there were 6 cases with cure,8 cases with marked effect,15 cases with effect,10 cases with no-effect in control groupâ… .Total efficiency was 64.10%;there were 3 cases with cure,4 cases with marked effect,18 cases with effect,14 cases with no-effect in control groupâ…¡. For 2 months after the treatment, total efficiency was 85.00%;there were 7 cases with cure,6 cases with marked effect,21 cases with effect,6 cases with no-effect in treatment group. Total efficiency was 69.23%;there were 4 cases with cure,6 cases with marked effect,17 cases with effect,12 cases with no-effect in control groupâ… . Total efficiency was 58.97%; there were 1 cases with cure,2 cases with marked effect,20 cases with effect,16 cases with no-effect in control groupâ…¡.â‘¢Treatment group was better than the two control groups; there were statistical significance(P<0.05) for both of after the treatment and 2months after it.(2)Symptom score:after the treatment and 2 months after it, the symptom scores were reduced obviously in each group; treatment group was better than the two control groups;there were statistical significance(P<0.05).(3)Single symptom:after the treatment, there were obvious improvement of postprandial fullness, early statiety, belth, which could last till 2 months after the treatment except belth(for both of the two control groups) in each group;heartburn and pantothenic acid, easy irritability, insomnia for both of treatment group and control groupâ… , which could not last till 2 months after the treatment for control groupâ… ;treatment group was better than the two control groups;there were statistical significance(P<0.05),except postprandial fullness, early statiety. (4)SF-36 scale:after the treatment and 2 months after it, there were obvious improvement of role of physiology and body pain;role of emtion,mind health, general health, social function, vitality;which could not last till 2 months after the treatment for controlâ… ; treatment group was better than the two control groups for all the dimensions above;there were statistical significance(P<0.05). But it is not invalid for physiological function in each group(P>0.05).(5)Safety evaluation and no-response case:after the treatment, there were no abnormality in each group for the safety test items such as liver and renal function, heart rate, blood pressure. During the treatment, we observed 1 case scalded slightly on the back of the food skin in treatment group;after advised to adjust the temperature of water solution, he persisted in the treatment; also, there was 1 case sufferded from thirst in control groupâ…¡, after advised to drink more water, she persisted in the treatment. There was one no-response case in both of control group I and control group II.ConclusionsMinor Decoction of Bupleurum per os coordinating foot massage is an safe, effective and new treatment for postprandial distress syndrome with incoordination between liver and stomach, which is suitable for improvement of clinical symptom and quality of life.