Related Research On Risk Factors Of Thrombosis In Patients With Ulcerative Colitis

Objective:To investigate plasma levels of D-dimer, F1+2, IL-6, TNF-α, sICAM-1, sVCAM-1,P-selectin and to analyze determinants or risk factors of D-dimer and F1+2, and further to evaluate the relationship between inflammation and coagulation parameters in UC patients.Methods: Between November 2008 to May 2010, 74 patients with UC (active UC 58; inactive 16) and 24 healthy controls were enrolled. The recruited patients were hospitalized and followed up at the outpatient clinic of our department. The clinical data of UC patients were collected. CRP, ESR, platelet counts were evaluated by traditional methods. IL-6, TNF-α, sICAM-1, sVCAM-1,P-selectin,D-dimer and F1+2 were measured by ELISA. Normally distributed data were analyzed by one-way ANOVA, and not normally distributed data were analyzed by Kruskal-Wallis test. Pearson's or Spearman's correlation was used to determine correlated variables. Linear regression and binary logistic regression were used to identify determinants of F1+2 and D-dimer.Results: Both active and inactive UC patients had significantly higher proportions of elevated D-dimer (active UC 62.1%; inactive UC 31.3%, respectively) and F1+2(active UC 72.4%; inactive UC37.5%, respectively) than healthy controls (4.2%; 8.3%, respectively). Correlation analyses revealed correlation between disease activity (r=0.370, p=0.010), IL-6 (r=0.369, p=0.010), TNF-α(r=0.228, P=0.020) and D-dimer. There was correlation between IL-6 (r=0.337, p=0.019) and F1+2. Linear regression identified the following determinants of elevated D-dimer: IL-6 (β=0.004, p=0.005), disease activity (β=0.082, p=0.004), TNF-α(β=0.147, p=0.000). IL-6 (β=0.029, p=0.009) was also determinant of increased F1+2. Logistic regression analyses revealed disease activity (OR 0.857, 95% CI 0.758 - 0.967; p=0.013) and IL-6 (OR 2.488, 95% CI 1.082 - 5.721; p=0.032) were related to elevated D-dimer. IL-6 (OR 1.113, 95% CI 1.030 - 1.202; p=0.007) was also independently associated with increased F1+2.Conclusions: D-dimer and F1+2 increased in active UC patients, and might persist in remission. Disease activity, IL-6 and TNF-αmight be important determinants of D-dimer and F1+2 in UC. These results also suggested that inflammation might induce abnormal coagulation.