The Study Of The Relationship Between Inflammatory Mechanisms And Stasis Heat Symptoms Of Hypertension Associated With Insulin Resistance And The Intervention Of Zhenjian Particles

Objective:To discuss the relationship between the hypertension and insulin resistance, and then study the relationship between inflammatory mechanisms and Stasis heat symptoms, To confirm the zhenjian particles can inhibit the inflammation and improve the Stasis heat symptoms.Methods:A total of 90 cases observed in patients with hypertension, According to the rating of HOMA-IR, these patients were divided into two groups, forty with IR and fifty with NIR, all patients were calculated points of Stasis heat symptoms and tested the FPG,FINS,TNF-α,IL-6,hs-CRP and lipid, to ensure that the experimental safety, the safety indexes were also tested. After that, the forty patients with IR were divided into two groups at random. There was no obvious difference in age, sex, illness course and severity degree between the two groups. The control group were treated by west medicine, while patients in the treatment group were treated by zhenjian particles everytime twice everyday on the basis of west medicine. The course of treatment lasted eight weeks, then the changes of insulin of laboratory indexes, the clinical symptoms and the degree of insulin resistance were observed.Results:1.There was a Significant correlation between the calculated points of Stasis heat symptoms and TNF-α,IL-6,hs-CRP in the patients with IR.2.After treatment,in the treatment group,the level of SBP,DBP,TG,FPG,FINS HOMA-IR were more remarkably reduced than in control group and the difference was significant between the two groups(P<0.05orP<0.01). The level of TNF-α,IL-6,hs-CRP in treatment group decreased more significantly than in control group, and the difference between two groups was statistical(P<0.05).At the aspect of treatment effect of traditional medicine, which in treatment group was ameliorated better than in the control group, and between the two groups difference was statistical(P<0.01).Conclusion:1.As one of the mechanisms of insulin resistance, the inflammatory mechanisms and Stasis heat symptoms have significant correlation.2. The zhenjian particles which function is qingganxiere and huayulishui can inhibit inflammation and improve insulin resistance and recuperate lipid.