| F-ERG reflects comprehensive reaction of the retina by light -stimulation, it is a kind of diagnostic method which evaluate the retinal function inside the ganglion cells. It has good diagnostic significance on extensive retinopathy. The premature and low birthweight infant has poor viscera function of body at birth. With development of perinatology and pediatrics, because the survival rate of premature and low birthweight infant raises obviously, the incidence of retinopathy of prematurity (ROP) rises. It needs good optesthesia during the growth, but the mature growth of retinal structure and function is interfered by premature and ROP. It is necessary to check the retinal function of premature and infant with ROP. The infant can't express anomalopia, and mild disorder of visual function cannot be found by common inspection. The examination of f-ERG is operated in sleeping. There are many merits, such as objective, atraumatic and repetitive, so it is the suitable examination which objectively evaluates the growth of retinal function. The research found out that the retinal function of premature and infant with ROP lags behind that of full-term infant at birth, but we compared the response of ERG on ROP infant, premature, full-term infant at different month, and we observed the growth of the retinal function. Adult was the group of comparison.Objective: We make this study to investigate the development of influence to the retinal function of premature and infant with ROP. We also want to compare the growth of retinal function of premature and infant with ROP to that of full-term infant.Methods: 1. Detection of ocular fundus: newborn infants were examined on ocular fundus in our ROP screening center from November 2008 to October 2009. Investigated object: (1) Preterm infant is the living newborn infant with gestational age less than 37 weeks and weight less than 2500 gram. (2) Full-term infant is living newborn infant with gestational age from 37 to 42 weeks and weight more than 2500 gram. (3) Adult is healthy volunteer that they don't have ophthalmic disease and diseases of whole body. We use direct or indirect ophthalmofundoscope and Retcamâ…¡wide-area digital retinal detection system to examine ocular fundus. Dividing groups through results of ocular fundus: ROP (+) group, ROP (-) group, full-term infant group and healthy adult group. Ocular fundus of ROP (+) group was investigated till disease had disappeared.2. Examination of ERG: Infant among ROP (+), ROP (-) and full-term infant groups were examined at corrected gestational-age of 40 weeks (0 month), 53 weeks (3 month) and 65 weeks (6 month). Healthy adult group was examined once.3. Use test of normality and homogeneity test for variance to check data. Use SPSS 13.0 systems software and one-way anova (LSD and SNK) to analyze results.Results:1.Results of Ocular fundus : 55 eyes were in ROP(+) group. 34 cases were zone 3 and stageâ… , and 21 cases were zone 3 and stageâ…¡. The disease involved range less than 8 clocks. Desease of 55 cases dispeared at 3 month, and the retina was completely vascularized. There were not disease of ocular fundus in ROP (-) group, full-term infant, adult group.2. Results of f-ERG examination2.1 Comparison between ROP (+) group and full-term infant group 0 month: Implicit times of a wave in the cone response and number of OPs wave are not obviously different in two groups (P=0.115>0.01). It hasn't statistical significance. In two groups, there are obvious difference on amplitude of a wave in the cone response, implicit times and amplitude of b wave in the rod and cone response, implicit times and amplitude of a and b wave in the maximal mixed response, amplitude of OPs(P<0.01). It has statistical significance.3 month: Implicit times of a and b wave in maximal mixed response, implicit times of b wave in the cone response and number of OPs wave are not obviously different in two groups (P>0.01). It hasn't statistical significance. There are obvious difference on implicit times and amplitude of b wave in the rod and a wave in the cone response ,amplitude of b wave in the cone response, amplitude of a and b wave in the maximal mixed response, amplitude of OPs (P<0.01). It has statistical significance.6 month: Implicit times and amplitude of b wave in the rod response, a and b wave in the cone response, amplitude of a and b wave in maximal mixed response, OPs wave are not obviously different in two groups (P>0.01). It hasn't statistical significance. There are obvious difference on implicit times of a and b wave in the maximal mixed response, amplitude of OPs (P<0.01). It has statistical significance.2.2 Comparison between ROP (-) group and full-term infant group0 month: Implicit times of a and b wave in the cone response and the number of OPs wave are not obviously different in two groups (P>0.01). It hasn't statistical significance. There are obvious difference on amplitude of a and b wave in the cone response, implicit times and amplitude of b wave in the rod, implicit times and amplitude of a and b wave in the maximal mixed response, amplitude of OPs (P<0.01). It has statistical significance.3 month: Implicit times and amplitude of a wave in maximal mixed response, a and b wave in the cone response and number of OPs wave are not obviously different in two groups (P>0.01). It hasn't statistical significance. There are obvious difference on implicit times and amplitude of b wave in the rod and b wave in the maximal mixed response, amplitude of OPs (P<0.01). It has statistical significance.6 month: Amplitude of b wave in the rod response, a and b wave in the cone and maximal mixed response, the number of OPs wave are not obviously different in two groups (P>0.01). It hasn't statistical significance. There are obvious difference on implicit times of b wave in the rod response, a and b wave in the maximal mixed response, amplitude of OPs (P<0.01). It has statistical significance.2.3 Comparison between ROP (-) group and ROP (+) group 0 month: Implicit times of a and b wave in the cone response, the number and amplitude of OPs wave are not obviously different in two groups (P>0.01). It hasn't statistical significance. There are obvious difference on amplitude of a and b wave in the cone response, implicit times and amplitude of b wave in the rod, implicit times and amplitude of a and b wave in the maximal mixed response(P<0.01). It has statistical significance.3 month: Implicit times of a wave in maximal mixed response, amplitude of b wave in maximal mixed response, implicit times and amplitude of a and b wave in the cone response and number of OPs wave are not obviously different in two groups (P>0.01). It hasn't statistical significance. There are obvious difference on implicit times and amplitude of b wave in the rod, implicit times of b wave in maximal mixed response, amplitude of a wave in maximal mixed response, amplitude of OPs (P<0.01). It has statistical significance.6 month: Implicit times and amplitude of b wave in the rod response, implicit times and amplitude of a and b wave in the cone response and maximal mixed response, the number of OPs wave are not obviously different in two groups (P>0.01). It hasn't statistical significance. There are obvious difference on amplitude of OPs (P<0.01). It has statistical significance.2.4 Comparison between ROP (+) group and healthy adult groupThere are obvious difference on implicit times of b wave in the rod response, implicit times of a and b wave in the maximal mixed response, implicit times of a and b wave in the cone response (P<0.01). It has statistical significance. It has statistical significance at 6 month(P>0.01).At 0, 3, 6 month, the percentages of amplitude of b wave in the rod response are13.01%, 23.96%, and 44.71%. The percentages of amplitude of a wave in the maximal mixed response are 24.37%, 42.20% and 72.08%. The percentages of amplitude of b wave in the maximal mixed response are 22.13%, 42.81% and 69.03%. The percentages of OPs'amplitude are 15.01%, 23.66% and 30.03%. The percentages of amplitude of a wave in the cone response are 32.69%, 48.50% and 67.75%. The percentages of amplitude of b wave in the cone response are26.00%, 42.02% and 58.70%.2.5 Comparison between ROP (-) group and healthy adult group There are obvious difference on implicit times of b wave in the rod response, implicit times of a and b wave in the maximal mixed response, implicit times of a and b wave in the cone response (P<0.01). It has statistical significance. It has statistical significance at 6 month(P>0.01).At 0, 3, 6 month, the percentages of amplitude of b wave in the rod response are15.19%, 28.35% and 44.57%. The percentages of amplitude of a wave in the maximal mixed response are 33.05%, 49.49% and 61.63%. The percentages of amplitude of b wave in the maximal mixed response are 30.19%, 45.56% and 69.66%. The percentages of OPs'amplitude are 13.22%, 26.13% and 35.29%. The percentages of amplitude of a wave in the cone response are 40.67%, 52.52% and 64.19%. The percentages of amplitude of b wave in the cone response are 31.17%, 43.10% and 57.78%.2.6 Comparison between full-term infant group and healthy adult group There are obvious difference on implicit times of b wave in the rod response, implicit times of a and b wave in the maximal mixed response, implicit times of a and b wave in the cone response (P<0.01). It has statistical significance. It has statistical significance at 6 month(P>0.01).At 0, 3, 6 month, the percentages of amplitude of b wave in the rod response are26.80%, 33.80% and 45.43%. The percentages of amplitude of a wave in the maximal mixed response are 41.90%, 53.50% and 69.81%. The percentages of amplitude of b wave in the maximal mixed response are35.90%, 54.95% and 73.36%. The percentages of OPs'amplitude are 17.96%, 30.83% and 39.08%. The percentages of amplitude of a wave in the cone response are 53.45%, 59.70% and 67.26%. The percentages of amplitude of b wave in the cone response are 37.54%, 50.26% and 63.90%.Conclusion: 1 Preterm factors and mild ROP influence the response of ERG. Implicit times obviously extend and amplitude obviously reduce. Preterm factors and mild ROP obviously influence the retinal function.2 With disapear of ROP and growth of age, Implicit times and amplitude equivalents to that of full-term infants at 6 month, except Ops.3 Compared to adult, ERG of full-term is obviously different at birth. Implicit times close to adult, amplitude is more lower. Implicit times grow more quickly than adult at 6 month.4 F-ERG is appropriate method for examining the retinal function of infants.
|
PDF Full Text Request