Relationship Between Serum Amyloid A,C-Reactive Protein And Micro Inflammation State In Patients With Chronic Renal Failure

Objective To study the levels of serum amyloid A (SAA),c reactive protein(CRP) and explore their relationship with CRF micro inflammation.Methods 100 CRF patients, include 70 non-dialytic (ND)which are divided into three periods, CKD2-3 period, CKD4 period, CKD5 period according to DOQI K/guide, 30 hemodialysis (HD), and 20 normal controls.Collection of each group's height, weight, renal function, hemoglobin, serum albumin, blood lipids, C-reactive protein, echocardiography and other clinical data, SAA level was tested by enzyme-linked immunosorbent assay (ELISA).Results The average levels of SAA,CRP in CRF patients were significantly higher than those in normal control group (p<0.05), and were significantly higher in HD group as compared with ND group(p<0.01). The levels of SAA have significant differences in the four groups with CRF (p<0.01).However, the differences of the levels of CRP between CKD2-3period and CKD4 period were not significant(p>0.05).SAA,CRP levels increased with the progression of renal dysfunction. SAA,CRP levels were positively correlated with serum creatinine (r=0.901,0.840, p<0.01), abnormal echocardiography (r=0.828,0.720, p<0.01) and cardiovascular disease (r=0.413,0.452, p<0.01). SAA,CRP levels were negatively correlated with hemoglobin (r=-0.697,-0.535, p<0.01), serum albumin (r=-0.685,-0.627, p<0.01).Conclusions CRF patients had serum SAA,CRP levels rise. Compared with CRP, SAA was earlier in reflecting the micro-inflammatory status which might contribute to anemia,malnutrition and cardiovascular disease in patients with CRF.