Expression And Significance Of Trail, Dcr1, And Survivin In Colorectal Carcinoma

Objective:To study the expression and significance of. TRAIL (TNF-relatedapoptosis-inducingligand),DcRland Survivin in colorectal carcinoma.To investigate the possible roles of TRAIL,DcR1 and Survivin in the course of the incidence of colorectal cancer,to provide the clinical experimental basis for TRAIL.Methods:S-P immunohistochemical technique was used to examine the expression of TRAIL, DcR1 and Survivin in 39 cases of colorectal carcinoma and the Surrounding tissues of 1cm distance and the tissues of its resection margin. The level of the expression was analyzed combined with clinicopathological features of age and sex of the cases, the size and loci of the tumor, infiltration depth, differentiation degree, naked eye and histology type, lymphnode metastasis and Dukes-stages.Results:The color of the immune positive products ofTRAIL,DcR1,and Survivin was buffy and located in cytoplasm or plasmalemma. The rate of positive expression of TRAIL was 25.64%(10/39),74.36%(29/39) and 84.62%(33/39) in colorectal carcinoma, Surrounding tissues and resection margin tissues and the differences between carcinoma and Surrounding tissues or resection margin tissues was obvious(P<0.01).there was no differences between Surrounding tissues and resection margin tissues(p>0.05). The rate of positive expression of DcR1 was 21.05%(10/38),57.89%(22/38) and 86.84%(33/38) in colorectal carcinoma, Surrounding tissues and resection margin tissues respectively. The expression of DcR1 was decreased in colorectal carcinoma and has a significant differences with Surrounding tissues and resection margin tissues (P<0.01). The expression of DcR1 was increased by degrees in colorectal carcinoma, Surrounding tissues and resection margin tissues.The rate of positive expression of Survivin was 71.79%(28/39),23.08%(9/39),7.69%(3/39) in colorectal carcinoma, Surrounding tissues and resection margin tissues respectively. The expression of Survivin was increased in colorectal carcinoma and has a significant difference with Surrounding tissues and resection margin tissues (P<0.01). The expression of TRAIL was no obe in moderate and poor differentiation degree than those in high differentiation degree and the rate of positive expression was 8.7%(2/23) and 50%(8/16) respectively(P<0.05). The expression of DcR1 was no significant differences in moderate and poor differentiation degree and those in high differentiation degree and the rate of positive expression was 21.53%(5/23) and 20.00% (3/15) respectively(P=1>0.05). The expression of Survivin was higher in moderate and poor differentiation degree than those in high differentiation degree and the rate of positive expression was 80.00%(16/20) and 40.91%(9/22) respectively (P<0.01). There were no significant differences in the age and sex of the cases, the size and loci of the tumor, infiltration depth, naked eye and histology type, lymph node metastasis and Dukes-stages of the expression of TRAIL,DcR1, and Survivin (P>0.05).The expression of TRAIL was significant correlated to those of DcR1 (P<0.05,r=0.4233).Conclusion:TRAIL, DcR1 and Survivin may be closely correlated to the occurrence and the development of colorectal carcinoma. The expression of DcR1 was decreased, but Survivin was increased while TRAIL was decreased in colorectal carcinoma. The expression of TRAIL was significant correlated to those of DcR1. Depress the expression of Survivin may promote the sensitivity of anti-tumor effect of TRAIL.