The Expression Of Survivin And Vegf In Renal Cell Carcinoma And Their Clinical Significance

Objective To investigate the expression of Survivin protein and VEGF protein in the tissue of normal kidney and renal cell carcinoma (RCC) (Including different pathological grades or clinical stages).To investigate their correlation and find their clinical significance in diagnosis and prognosis evaluation of RCC.Method The expression of Survivin and VEGF protein in the tissue of 32 cases of RCC and 10 cases of normal kidney was examined by Streptavidin-Peroxidase (SP) immunohistochemistry.Each group were analyzed by SPSS 11.5 for Windows software. Results 1,There was no Survivin and VEGF protein expressed in the tissue of normal kidney.2,Survivin protein was significantly expressed in the tissue of RCC.It was expressed in 53% of the RCC group.In the poorly differentiated group,the differentiation group and the well-differentiated group,Survivin was differently expressed in the rate of 100%,66.6%,38.1%.InⅠandⅡperiod group,Survivin was expressed in the rate of 33.3%,while inⅢandⅣperiod group,the rate was 90.9%. There was statistically significant difference.3,VEGF was significantly expressed in the tissue of RCC.It is expressed in 34.4% of the RCC group.In the poorly differentiated group,the differentiation group and the well-differentiated group,VEGF was differently expressed in the rate of 100%,33.3%,19.9%.InⅠandⅡperiod group,Survivin was expressed in the rate of 14.3%,while inⅢandⅣperiod group,the rate was 72.7%,There was statistically significant difference.4,The expression of Survivin and VEGF were positively correlated in RCC. r=0.416 P<0.05.Conclusion 1,The expression of Survivin and VEGF were significantly higher in RCC than in normal kidney tissue,while There was no Survivin and VEGF protein expressed in the tissue of normal kidney group.2,The expression of Survivin and VEGF in RCC were positively related to the pathological grades and clinical stages.The expression of Survivin and VEGF in the poorly differentiated group and the differentiation group was higher than in the well-differentiated group,and the expression inⅢandⅣperiod group was also higher thanⅠandⅡperiod group.3. The expression of Survivin and VEGF were positively correlated in RCC,which suggests that they might play an important role in carcinogenesis and the development of RCC.Survivin and VEGF Detecting could be widely used in diagnosis and prognosis evaluation of RCC.