Expression And Significance Of Integrinα₅β₁, Integrinα_v β₃ And Fak In Epithelial Ovarian Cancer

Objective:To investigate the expression of integrinα₅β₁,integrinα_vβ₃ and FAK in epithelial ovarian cancer and its relationship with the development and prognosis of the epithelial ovarian cancer.Methods:The expression of integrinα₅β₁,integrinα_vβ₃ and FAK were examined by immunohistochemical S-P staining method in 49 cases with epithelial ovarian cancer, 15 cases with benign epithelial ovarian tumors and 10 cases with normal ovarian tissue and discuss the relationship of expression and clinical pathological mechanism and prognosis among the triple.Results:Detecting the expression of integrinα₅β₁ in each group of the ovarian tissue by S-P immunohistochemistry method,Discovered that integrinα₅β₁-positive expression in epithelial ovarian cancer, benign epithelial ovarian tumors and normal ovarian tissue was 66.2%, 26.7% and 30.0%. The expression of integrinα₅β₁ among epithelial ovarian cancer, benign epithelial ovarian tumors and normal ovarian tissue groups had the remarkable difference (P<0.05).Detecting the expression of integrinα_vβ₃ in each group of the ovarian tissue by S-P immunohistochemistry method, Discovered that integrinα_vβ₃-positive expression in epithelial ovarian cancer, benign epithelial ovarian tumors and normal ovarian tissue was 77.6%, 33.3%, and 10.0%. The expression of integrinα_vβ₃ among epithelial ovarian cancer with benign epithelial ovarian tumors and normal ovarian tissue groups had the remarkable difference (P<0.05).Detecting the expression of FAK in each group of the ovarian tissue by S-P immunohistochemistry method, Discovered that FAK -positive expression in epithelial ovarian cancer, benign epithelial ovarian tumors and Normal ovarian tissue was 69.4%, 20.0% and 10.0%. The expression of FAK among epithelial ovarian cancer with benign epithelial ovarian tumors and normal ovarian tissue groups had the remarkable difference (P<0.05).In ovarian epithelial carcinoma tissues, The positive expressions of integrinα₅β₁,integrinα_vβ₃ and FAK was much higher than those of ovarian epithelial benign tumors and normal ovarian (P<0.05). The expression of integrinα_vβ₃ and integrinα₅β₁ was correlated with the histological grade and clinicopathological stage(P<0.05), It was not correlated with the age, the histological type and the size of tumours(P>0.05). The expression of FAK was correlated with clinicopathological stage (P<0.05) and was not with the others.According to Spearman rank relevance analysis, integrinα₅β₁ had positive correlation with FAK (r=0.490, P<0.01), integrinα_vβ₃ had positive correlation with FAK (r=0.499, P <0.01), integrinα₅β₁ had positive correlation with integrinα_vβ₃ (r=0.513, P <0.05).Conclusions:Integrinα₅β₁,integrinα_vβ₃ and FAK are all over expressed in ovarian epithelial carcinoma. The expression in integrinα₅β₁, integrinα_vβ₃ and FAK has a closely relationship. Integrinα₅β₁, integrinα_vβ₃ and FAK are prognostic indicators in patients with ovarian epithelial carcinoma.