Skullcap Anti-influenza Virus-based Chinese Medicines Influencing Factors Discussed

Traditional Chinese medicine have a complete theoretical system, with the overall concept and treatment based on syndrome differentiation to guide the clinical practice. Take this as a fundamental, pharmacy of Chinese materia medica has complexity and systematic characteristics,modern medicine continue to blend in with the multidisciplinary process and has also formed a comprehensive, multi-angle understanding.Radix Scutellariae is a classic medicine which is frequently used to clear heat and remove dampness in the diagnosis and treatment of traditional Chinese medicine, such as jaundice diarrhea, the lung hot cough, the fever bothersome thirsty, the painful fetal movement and so on. Modern research indicates that Radix Scutellariae has anti-inflammatory, antibacterial, antiviral, antipyretic, antihypertensive, diurstic and other pharmacological effects, which contains flavonoids as the main effect spot. The influenza many caused by the virus, therefore, there exist certain corresponding relationships between the therapeutic action of Radix Scutellariae and the virus. The paper first aims at the present experimental study situation of Radix Scutellariae, its antiviral function in clinical practice, as well as the research of the influenza to launches the summary, and systematically summarize the related research situation connect with the research purpose, which lay a foundation for the expand of the theory and experiment.Specific to a particular type, in the case of influenza, paying attention to its pharmacodynamic research and evaluation, investigating its different angles and the relative maturity of the animal model from traditional Chinese medicine point of view and endorse it. In the experimental part of this paper, adapted strain of influenza virus animal model of rat lung was used from the perspective of anti-virus. In other early experiments of our research group, we did anti-influenza virus infection experiments research on Radix Scutellariae from three different origins such as Hebei, Shanxi, Dalian, and the result showed that extractions from different sources all shows good anti-influenza virus effects, which in particular water extraction group of Hebei Radix Scutellariae shows the best effect. Follow by the analysis of Radix Scutellariae spectral activity relationship which use gray correlation analysis method combine with high performance liquid chromatography, ascertain that baicalin, wogonin, baicalein and other ingredients in the extractions of Radix Scutellariae show closely relationship with the anti-influenza virus, the contents of the Radix Scutellariae compositions are confirmed by the determination of the water extraction group of Hebei Radix Scutellariae. In this experiment a comparative study on the effects of the death protective effect to the mice which were infected with by influenza virus FM1, the lung index and lung virus hemagglutination titer between the water extraction group of Hebei Rdix Scutellariae and group of chemical composition Radix Scutellariae property. The result shows that chemical composition of Radix Scutellariae property group has good death protective effect to the mice which were infected with by influenza virus FM1 and has effect on reducing lung index and the hemagglutination titer of virus to the infected mice, which shows same therapeutic effectiveness with the water extraction group of Hebei Radix Scutellariae. This experiment confirms that the reasonable proportion of baicalin, wogonin and baicalein reflects the quality of the classic heat dampness medicine Radix Scutellariae efficacy and reveals the significance and support point view of the radix scutellariae in modern applications, which provides a reference for these similar drugs.In the study of theoretical part, we first focus on the overall pharmacodynamic characteristics of traditional Chinese medicine, and the discussion layers start on this basis. In recent years. research on the efficacy of traditional Chinese medicine more focus on the full range understanding of Chinese medicine objects, combined with the research method in pharmacology, pharmaceutical analysisresearch and other areas of multidisciplinary research techniques, given the traditional Chinese medicine with modern scientific content, and thus expand the traditional Chinese medicine correspondence between composition and efficacy of these cut into the perspective of an objective reflection of the efficacy of Chinese medicine controllable factors, and at the same time provide ideas for the evaluation of efficacy of Chinese medicine. On the other hand, on the basis of emphasis in Chinese medicine theory and extensive expansion, then further profoundly analyse the importance of the cognitive styles and thinking characteristics in the clinical application of traditional Chinese mdicine throughout the clinical process, and its dialectical and flexible quality which will integrated to present too many possible ways of thinking from the patients, spirit, colour, pulse and other specific performance, the impact of their doctors are indirectly reflected in the final efficacy relationship in the meantime. This is another focus of the paper. The material foundation and action mechanism of traditional Chinese medicine efficacy showing diverse trend,so the evaluation of the medicine efficacy should be a combination of factors from from a multi-perspective to conduct the evaluation. Select the suitable evaluation index, establish the disease and syndrome unified animal model, formulate appropriate experimental design nend clinical curative effect as the ultimate goal for investigate. In short, we should organicly combine the three aspects to further the correlative study of traditional Chinese medicine and its compound medicine about the their complex and varied chemical composition which have interaction and efficacy with the organism, so as to form mature and stable medicine efficacy research thought.