Gastric Stasis Syndrome Gene Expression And Cell Signaling Channel Protein Expression

The study of blood stasis syndrome has made great achievement in the field of the integration of Traditional Chinese and Western Medicine, ft concludes the application of pathophysiology, pathological anatomy, immunology and other modem scientific technique. Molecular biology has been used widely in the field of medicine, but the study of blood stasis concerned with the gene and genie expression is fewer.Malignant tumor is characterized of the lump in the clinic. In traditional Chinese medicine, the lump is closely related to the blood stasis. The pathological mechanism is blood stasis due to qi stagnation. Gastric carcinoma is one of the most common tumors in the clinic. To research the relationship between the different stages of tumor and the expression of related gene, we study the gastric carcinoma. According to current proverbial views, the generation of gastric carcinoma is classified with chronic gastritis (abbreviate: CG), intestinal metaplasia(abbreviate: IM), gastric dysplastic epithelia (abbreviate: GDE) and gastric carcinoma(abbreviate: GC). We adopted the SYDNEY category' system of international routine of the gastropathy to study the relationship between the blood stasis syndrome of different stages of gastric carcinoma and the degree and number of expression of oncogene and oncocyte. The aim is to provide the diagnosis proofs of the blood stasis syndrome of gastric carcinoma in the molecular level.Recent research shows that it is many factors leading to the generation of gastric carcinoma. The blood stasis syndrome of gastric carcinoma is summary manifestation of many factors caused. What's more, study of oncogene is the hot spot of the study of tumor, so we try to study the relationship between the blood stasis of different stages of gastric carcinoma and the expression of related genes.l.The relation of the blood stasis syndrome of gastric carcinoma and DNAtopoII expression:The biology action of DNAtopoII contrast control the supercoil tie knot of DNA or antiknot symbody behavior of DNA.Indirect influence to the process of intercell nucleic acid metabolism and direct preventive to interrupt the chain of DNAmoIecul,DNA recombination.plerosis transcription replication process ?2. .The relation of the blood stasis syndrome of gastric carcinoma and Ki-67 expression:The Ki-67 with stomach atypical hyperplasia degree,gastric carcinoma anisodifferentiation degree, gastric carcinoma histology typing intimate correlation.lt helps to judge the malignancy degree expression level of gastric carcinoma ?3. The relation of the blood stasis syndrome of gastric carcinoma and Phosphotyosine expression: Phosphotyosine plays important role to maintenance the endothelial cell barrier. Tyosine is a site of phosphory .The exponent of thosphotyosine is higher,its maybe relationship with the endothelial cell structure and the blood vessel permeability.lt made the thrombocyiopoiesis releas and collecting response.Therefore the blood-stasis symptom became severity.